التفاصيل البيبلوغرافية
| العنوان: |
Rapid magnetic heating treatment by highly charged maghemite nanoparticles on Wistar rats exocranial glioma tumors at microliter volume. |
| المؤلفون: |
Rabias, Ioannis, Tsitrouli, Danai, Karakosta, Eleni, Kehagias, Thomas, Diamantopoulos, Georgios, Fardis, Michael, Stamopoulos, Dimosthenis, Maris, Thomas G., Falaras, Polykarpos, Zouridakis, Nikolaos, Diamantis, Nikolaos, Panayotou, Georgios, Verganelakis, Dimitrios A., Drossopoulou, Garyfalia I., Tsilibari, Effie C., Papavassiliou, Georgios |
| المصدر: |
Biomicrofluidics; Jun2010, Vol. 4 Issue 2, p024111, 8p, 1 Color Photograph, 2 Diagrams, 1 Graph |
| مصطلحات موضوعية: |
NANOPARTICLES, MAGNETIC fields, LABORATORY rats, MAGHEMITE, TUMORS, MAGNETICS |
| مستخلص: |
One of the most significant challenges implementing colloidal magnetic nanoparticles in medicine is the efficient heating of microliter quantities by applying a low frequency alternating magnetic field. The ultimate goal is to accomplish nonsurgically the treatment of millimeter size tumors. Here, we demonstrate the synthesis, characterization, and the in vitro as well as in vivo efficiency of a dextran coated maghemite (γ-Fe2O3) ferrofluid with an exceptional response to magnetic heating. The difference to previous synthetic attempts is the high charge of the dextran coating, which according to our study maintains the colloidal stability and good dispersion of the ferrofluid during the magnetic heating stage. Specifically, in vitro 2 μl of the ferrofluid gives an outstanding temperature rise of 33 °C within 10 min, while in vivo treatment, by infusing 150 μl of the ferrofluid in animal model (rat) glioma tumors, causes an impressive cancer tissue dissolution. [ABSTRACT FROM AUTHOR] |
|
Copyright of Biomicrofluidics is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder