دورية أكاديمية
Synthesis of phosphonated carbocyclic 2 '-oxa-3 '-aza-nucleosides: Novel inhibitors of reverse transcriptase
| العنوان: | Synthesis of phosphonated carbocyclic 2 '-oxa-3 '-aza-nucleosides: Novel inhibitors of reverse transcriptase |
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| المؤلفون: | Chiacchio, U, Iannazzo, D, Piperno, A, Rescifina, A, Romeo, R, Saglimbeni, M, Sciortino, M, Valveri, V, Mastino, A, Romeo, G., BALESTRIERI, EMANUELA, MACCHI, BEATRICE |
| المساهمون: | Chiacchio, U, Balestrieri, E, Macchi, B, Iannazzo, D, Piperno, A, Rescifina, A, Romeo, R, Saglimbeni, M, Sciortino, M, Valveri, V, Mastino, A, Romeo, G |
| بيانات النشر: | Amer Chemical SOC US WASHINGTON |
| سنة النشر: | 2005 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | 5 fluoro 1 isoxazolidin 5 yl 1h pyrimidine 2,4 dione, antiretrovirus agent, carbocyclic 2' oxa 3' aza nucleoside, complementary DNA, diethyl [1' [4 amino 2 oxopyrimidin 1(2h) yl] 3' methyl 2' oxa 3' azacyclopent 4' yl]methylphosphonate, diethyl [1' [5 fluoro 2,4 dioxo 3,4 dihydropyrimidin 1(2h) yl] 3' methyl 2' oxa 3' azacyclopent 4' yl]methylphosphonate, diethyl [1' [[[5 methyl 2,4 dioxo 3,4 dihydropyrimidin 1(2h) yl]] 3' methyl 2' oxa 3' azacyclopent 4' yl]]methylphosphonate, isoxazolidine derivative, nucleoside analog, phosphonic acid derivative, RNA directed DNA polymerase, RNA directed DNA polymerase inhibitor, unclassified drug, virus RNA, zidovudine, antiviral activity, article, cell strain HL 60, cell strain U937, cytotoxicity, drug structure, drug synthesi, enzyme inhibition, Hepatitis B viru, human, human cell, Human immunodeficiency virus 1, lymphoid cell, nonhuman, proton nuclear magnetic resonance |
| الوصف: | Phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides have been synthesized in good yields by 1,3-dipolar cycloaddition methodology. The cytotoxicity and the reverse transcriptase inhibitory activity of the obtained compounds have been investigated. Phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides, while showing low levels of cytotoxicity, exert a specific inhibitor activity on two different reverse transcriptases, which is comparable with that of AZT, opening new perspectives on their possible use as therapeutic agents, in anti-retroviral and anti-HBV chemotherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/15743182; info:eu-repo/semantics/altIdentifier/wos/WOS:000227392200011; volume:48; issue:5; firstpage:1389; lastpage:1394; numberofpages:6; journal:JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/2108/41896Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-20144371736 |
| DOI: | 10.1021/jm049399i |
| الإتاحة: | https://doi.org/10.1021/jm049399iTest http://hdl.handle.net/2108/41896Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F27A25EB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/jm049399i |
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