رسالة جامعية
Comparative efficacy of three common treatments for equine recurrent airway obstruction
| العنوان: | Comparative efficacy of three common treatments for equine recurrent airway obstruction |
|---|---|
| المؤلفون: | Lee, Laura Caryn |
| مرشدي الرسالة: | Veterinary Medical Sciences, Zimmerman, Kurt L., Witonsky, Sharon G., Buechner-Maxwell, Virginia A. |
| بيانات النشر: | Virginia Tech, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | Virginia Tech Theses and Dissertation |
| Original Material: | etd-07102009-190004 |
| مصطلحات موضوعية: | Pulmonary Function Testing, Airway Inflammation, Asthma, Equine Recurrent Airway Obstruction (RAO), Equine Heaves, Allergy, Dexamethasone, Environmental Modification, Airway Neutrophilia, Bronchoalveolar Lavage Fluid |
| الوصف: | Objective - evaluate horses with acute airway obstruction using three treatment regimens: tapering doses of dexamethasone (DEX), environmental modification (ENV), and a combination of both treatments (DEX + ENV) by analyzing clinical parameters, pulmonary function testing, bronchoalveolar lavage fluid (BALF) cytology and BALF cell expression of the cytokines IFN-? and IL-4 Animals - 6 horses with recurrent airway obstruction (RAO) Procedures - Clinical examination, pulmonary function test, and collection of BALF prior to treatment and during 22 day treatment period Hypothesis - Alterations in clinical parameters, pulmonary function and airway inflammation in acute equine RAO will return to remission values by treating with DEX, ENV or DEX + ENV Results - All horses demonstrated clinical disease, reduced pulmonary dynamic compliance (Cdyn) and an increased maximum change in pleural pressures (?Pplmax) when in a challenge environment. All treatments improved clinical parameters, ?Pplmax and Cdyn. BALF cytology during an RAO crisis demonstrated neutrophilic inflammation. ENV or DEX + ENV resulted in a significant decrease in airway neutrophilia that was maintained throughout the treatment period. In contrast, treatment with DEX caused a reduction in airway neutrophilia initially followed by a rebound neutrophilia as the period between administrations of dexamethasone (0.05mg/kg) was increased to 72 hours. The rebound neutrophilia was not accompanied by equivalent deterioration in clinical parameters or pulmonary function. Conclusions - Environmental modification is important in the management of RAO horses. Treatment of clinical RAO with a decreasing dosage protocol of corticosteroids in the absence of environmental modification results in the persistence of airway inflammation without recrudescence of clinical disease. Master of Science |
| Original Identifier: | oai:vtechworks.lib.vt.edu:10919/76818 |
| نوع الوثيقة: | Thesis Text |
| وصف الملف: | application/pdf |
| الإتاحة: | http://hdl.handle.net/10919/76818Test http://scholar.lib.vt.edu/theses/available/etd-07102009-190004Test/ |
| حقوق: | In Copyright URL: http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsndl.VTETD.oai.vtechworks.lib.vt.edu.10919.76818 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |