دورية أكاديمية
Low grade gliomas in children and adults can be molecularly graded
| العنوان: | Low grade gliomas in children and adults can be molecularly graded |
|---|---|
| المساهمون: | Yang, Rui (author.), Ng, Ho-Keung (thesis advisor.), Chinese University of Hong Kong Graduate School. Division of Anatomical and Cellular Pathology. (degree granting institution.) |
| سنة النشر: | 2019 |
| المجموعة: | The Chinese University of Hong Kong: CUHK Digital Repository / 香港中文大學數碼典藏 |
| مصطلحات موضوعية: | Gliomas, NAD(P)H dehydrogenases, Glioma, Isocitrate Dehydrogenase--genetics, Adult, Child |
| الوصف: | Ph.D. ; Gliomas are the most common primary brain tumors in adults and children. Gliomas are subdivided in the 2016 WHO classification of tumors of the Central Nervous System (CNS) by histological grade and molecular features, particularly IDH. In this study, I focused on low-grade gliomas in adults and children. According to the 2016 WHO classification, Isocitrate dehydrogenase (IDH) gene is a crucial requisite for the classification of lower-grade astrocytomas in adults. Adult astrocytomas are classified as IDH-mutant or IDH-wildtype based on IDH status and the lack of 1p/19q codeletion. Adult IDH-mutant lower-grade astrocytomas (IDH-mutant LGGs) comprise diffuse astrocytoma, Grade II and anaplastic astrocytoma, Grade III. Pediatric low-grade gliomas (PLGGs) are a heterogeneous group, however, and the 2016 WHO classification did not specify a classification for PLGGs. ; IDH mutation is now regarded as a good prognostic marker in adult lower-grade astrocytomas. Yet, the molecular and clinical heterogeneities of IDH-mutant lower-grade astrocytomas have not been extensively investigated. Pediatric low-grade gliomas (PLGGs) consist of a number of entities with overlapping histological features. PLGGs have much better prognosis than the adult counterparts, but a significant proportion of PLGGs suffer from tumor progression and recurrence. I hypothesize the adult IDH-mutant LGGs can be further stratification for risk. The same applies to pediatric low-grade gliomas. ; To identify the distinct molecular features of adult IDH-mutant lower-grade astrocytomas and pediatric low-grade gliomas and, we evaluated in two large cohorts of 160 IDH-mutant LGGs and 289 PLGGs a list of biomarkers and examined their clinical relevance. TERT promoter (TERTp), H3F3A and BRAF V600E mutations were detected by direct sequencing. ATRX nuclear loss and p53 expression were examined by immunohistochemistry. CDKN2A deletion, CDK4 amplification, PDGFRA amplification, KIAA1549-BRAF fusion, and MYB amplification were determined by fluorescence ... |
| نوع الوثيقة: | text |
| وصف الملف: | electronic resource; remote; 1 online resource (18 unnumbered leaves, 173 leaves) : illustrations (some color); computer; online resource |
| اللغة: | English Chinese |
| العلاقة: | cuhk:2398868; local: ETD920201130; local: AAI27784081; local: 991039875422403407; https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991039875422403407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_USTest; https://repository.lib.cuhk.edu.hk/en/item/cuhk-2398868Test |
| الإتاحة: | https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991039875422403407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_USTest https://repository.lib.cuhk.edu.hk/en/item/cuhk-2398868Test |
| حقوق: | Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-NoDerivatives 4.0 International" License (http://creativecommons.org/licenses/by-nc-nd/4.0Test/) |
| رقم الانضمام: | edsbas.C75A1169 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |