دورية أكاديمية
調控脊髓基因對於針刺痛之影響(第三年)
| العنوان: | 調控脊髓基因對於針刺痛之影響(第三年) |
|---|---|
| المؤلفون: | 孫維仁 |
| بيانات النشر: | 臺北市：國立臺灣大學醫學院麻醉科 |
| سنة النشر: | 2003 |
| المجموعة: | National Taiwan University Institutional Repository (NTUR) |
| مصطلحات موضوعية: | electroacupuncture, tail flick, formalin, c-fos expression, stimulation intensity, anesthesia |
| جغرافية الموضوع: | 計畫年度：91, 起迄日期：2002-08-01/2003-10-31 |
| الوصف: | Although induction of deep aching sensation, De-Qi, is generally accepted as a standard acupunctural practice, whether an intense nociceptive stimulation is required for optimal analgesic effect remains controversial. In freely moving rats we first demonstrated that intramuscular injection of 100 μl 5% formalin, a noxious irritant, in the Zusanli acupoint (ST-36) induced intense nociceptive behavior. Tail-flick latency and c-fos expression were then compared among halothane-anesthetized rats receiving either low-intensity electroacupuncture (10× threshold of local muscle contraction), high-intensity (20× threshold) electroacupuncture (30 min, 4Hz), intramuscular formalin, or normal saline injection at the right Zusanli acupoint. We found that formalin injection at the acupoint markedly increased tail-flick latency and induced greater c-fos expression at the superficial and deep laminae of spinal cord dorsal horn compared to saline injection. Electroacupuncture prolonged the cumulative tail-flick latency in an intensity-dependent manner but, in contrast to formalin, did not provide intensity sufficient to induce c-fos expression throughout the 2nd to 5th lumbar segments. Our data indicated that although noxious chemical stimulation at the acupoint can elicit comparable analgesic effect, non-noxious electrical stimulations produce even greater analgesic responses in an intensity-dependent manner. These findings suggest that generation of intense aching sensation, De-Qi, is not required for the analgesic effect provided by electroacupuncture. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf; 132157 bytes |
| اللغة: | Chinese |
| العلاقة: | 912314B002241; http://ntur.lib.ntu.edu.tw/handle/246246/28870Test; http://ntur.lib.ntu.edu.tw/bitstream/246246/28870/1/912314B002241.pdfTest |
| الإتاحة: | http://ntur.lib.ntu.edu.tw/handle/246246/28870Test http://ntur.lib.ntu.edu.tw/bitstream/246246/28870/1/912314B002241.pdfTest |
| حقوق: | 國立臺灣大學醫學院麻醉科 |
| رقم الانضمام: | edsbas.A577054A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |