تقرير
高脂血症病患血管通透性之研究 ; THE STUDY OF VASCULAR PERMEABILITY CHANGE IN HYPERLIPIDEMIC PATIENTS
| العنوان: | 高脂血症病患血管通透性之研究 ; THE STUDY OF VASCULAR PERMEABILITY CHANGE IN HYPERLIPIDEMIC PATIENTS |
|---|---|
| المؤلفون: | 吳造中 |
| بيانات النشر: | 臺北市：國立臺灣大學醫學院內科 |
| سنة النشر: | 1998 |
| المجموعة: | National Taiwan University Institutional Repository (NTUR) |
| مصطلحات موضوعية: | 高脂血症, 血管通透性, 螢光光度計, 血-水屏障, Hyperlipidemia, Vascular Permeability, Fluorophotometry, Blood-aqueous Barrier |
| جغرافية الموضوع: | 計畫年度：87, 起迄日期：1997-08-01/1998-07-31 |
| الوصف: | 背景：過去有關人類血管壁通透性的研究極少，至今仍無任何一種方法可在臨床上使用 於測量血管的通透性．我們過去的研究已証實眼部螢光測定可用於測量高脂血兔子的血 管內皮功能之完整性．而且血管通透性與血中膽固醇濃度有關，且在動脈粥狀硬化的早 期便已發生變化． 目的：本研究乃利用眼-水屏障的測量（F60）來評估人類血管通透性的決定因子． 方法與結果：五十八位男性及74 位女性高脂血症病人(平均年齡：53.6 土10.6 歲）接受 危險因子，理學及生化學檢查及眼部前房螢光光度計測量檢查（F60 值），結果發現 F60 值在停經前婦女最低，男性較高，而停經後婦女最高．F60 值在老年人，糖尿病患 者及具血管硬化病變者較高，但在血中高密度膽固醇值 (HDL)大於60 mg/dl 者較低， 另外，F60 值與病人的年齡，危險因子的數目，血中膽固醇值，LDL 值，T-CHO/HDL 比值，LDL/HDL 比值呈負相關．多變異分析發現僅LDL/HDL 比值，年齡，糖尿病及血 中膽固醇濃度為F60 值的獨立決定因子． 結論：眼部前房螢光光度計測量法可非侵襲地評估人類血管的通透性．而決定血管通透 性的獨立因子包括病人的血脂濃度，年齡及有無糖尿病的病史等． ; Background. The transfer process in human arterial wall has been studied by only a few investigators. Currently, there is still no widely accepted and clinically noninvasive method to measure the systemic vascular permeability. In our previous study, we used fluorophotometry to evaluate the vascular endothelial integrity in vivo in hyperlipidemic rabbits. The vascular permeability change correlated well with the serum cholesterol level and occurred in the very early stage of atherosclerosis. Purpose. To evaluate the status of blood-aqueous barrier (F60) and to define the significant determinants of vascular permeability in human beings. Methods and Results. Fifty-eight males and 74 female patients (aged 53.6 ±10.6 years) received risk stratification, physical and blood chemistry examinatios. Fluorophotometry examination was also performed in these hyperlipidemic patients. The F60 value was the lowest in the premenopausal female, higher in male, and the highest in postmenopausal females. It was higher in the aged patients, those with diabetes mellitus, or those with vascular diseases. However, the F60 value was lower in the patients with HDL ≧ 60 mg/dl. The F60 value also correlated positively with the patients’ age, number of risk factors, cholesterol , LDL, T-CHO/HDL, LDL/HDL, glucose, and HbA1c levels, and correlated negatively with the HDL level. By multivariate stepwise linear regression analysis, the vascular permeability value correlated significantly with the LDL/HDL ratio, age, diabetes ... |
| نوع الوثيقة: | report |
| وصف الملف: | application/pdf; 51243 bytes |
| اللغة: | Chinese |
| العلاقة: | 872314B002210; http://ntur.lib.ntu.edu.tw/handle/246246/23395Test; http://ntur.lib.ntu.edu.tw/bitstream/246246/23395/1/872314B002210.pdfTest |
| الإتاحة: | http://ntur.lib.ntu.edu.tw/handle/246246/23395Test http://ntur.lib.ntu.edu.tw/bitstream/246246/23395/1/872314B002210.pdfTest |
| حقوق: | 國立臺灣大學醫學院內科 |
| رقم الانضمام: | edsbas.90CAB4AB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |