الملخص (بالإنجليزية): |
Objective To study the epidemiological characteristics, laboratory indexes, clinical symptoms and pathogen coinfection of respiratory Adenovirus in children in Hohhot City. Methods A total of 4 266 in patients with acute respiratory tract infection admitted to Maternal and Child Health Hospital of Inner Mongolia Autonomous Region from January 2020 to December 2021 were selected, and the polymerase chain reaction was used to analyze the polymerase chain reaction. RT-PCR was used to detect Adenovirus nucleic acid from throat swab samples of the children. Combined with general information, the epidemiological and clinical characteristics of Adenovirus were analyzed. A total of 206 children with positive Adenovirus nucleic acid test were selected as the positive group, and another 206 children with negative nucleic acid test were selected as the control group. According to the severity of symptoms, the positive group was divided into the severe group (n=17)and the non-severe group(n=189). The clinical characteristics, laboratory biochemical indicators and co-infection of the Adenovirus positive group and the control group, and the severe group and the non-severe group were compared respectively. Laboratory biochemical indicators mainly include white blood cell (WBC), neutrophil (NBC), procacitonin (PCT), C-reactive protein (C-reactive protein, CRP) and lactate dehydrogenase (LDH). Results In 4 266 children with acute respiratory tract infection, the total positive rate of Adenovirus was 4.83% (206/4 266), and there was no significant difference between males (5.25%, 131/2 495) and females (4.23%, 75/1 771) (X² =2.325, P>0.05). Summer (8.14%, 74/958) was the peak season of infection, and children aged from June to 6 years were easily infected with Adenovirus (87.86%, 181/206), the positive rate of each age group was significantly different (X² =28.332, P<0.05), and the infection rate in June to 1 year was the highest (6.72%, 33/491). The levels of CRP[5.78 (0.93, 16.18) mg/L] and NBC[4.82 (2.82, 8.20)×109 /L] in positive group were higher than those in control group [3.68 (0.50, 10.43) mg/L, 3.91 (2.01, 6.61)×109 /L],the differences were statistically significant (Z=-2.373, -2.614, all P<0.05). CRP [6.91 (2.29, 14.30) mg/L] and LDH [313.80 (278.45, 402.30) U/L] levels in critical group were higher than those in non-critical group [1.70 (0.50, 11.95) mg/L, 279.60 (249.15, 316.50) U/L], and the differences were statistically significant (Z=-2.027, -2.744, all P<0.05). The incidence of fever ≥ 39℃ (58.74%, 121/206), heat duration ≥ 9 days (14.08%, 29/206), diarrhea (8.74%, 18/206) and wheezing (7.28%, 15/206) in positive group was significantly different from that in control group[36.89%(76/206), 6.80% (14/206),3.40%(7/206),14.08%(29/206)] (X² =19.698, 5.842, 5.153, 4.987, all P<0.05). The incidence of wheezing symptoms in the severe group (35.29%, 6/17) was higher than that in the non-severe group (4.76%, 9/189), and the difference was statistically significant (X² =17.251, P<0.05). Compared with the control group, the children in the Adenovirus positive group were more likely to be complicated with tonsillitis, sinusitis and gastroenteritis (X² =4.796, 10.652, 7.828, all P<0.05). The most common clinical symptoms of Adenovirus infection in children were bronchopneumonia (51.94%, 107/206). In the Adenovirus positive group, the infection rate of co-bacteria was higher than that of co-virus and mycoplasma (X² =24.793, 23.298, all P<0.05). Conclusion Children aged from June to 6 years old in Hohhot are easily infected with respiratory Adenovirus, which leads to respiratory diseases mainly bronchopneumonia, often complicated with bacterial infection, suggesting that the prevention and treatment of respiratory Adenovirus infection should be strengthened in children in Hohhot. [ABSTRACT FROM AUTHOR] |