التفاصيل البيبلوغرافية
| العنوان: |
重症肺炎支原体肺炎患儿肺炎支原体 DNA 复制水平与病情的相关性. (Chinese) |
| العنوان البديل: |
Correlation between Mycoplasma pneumoniae DNA replication level and disease severity in children with severe Mycoplasma pneumoniae pneumonia. (English) |
| المؤلفون: |
方柯南, 王晶, 倪婧雯 |
| المصدر: |
Chinese Journal of Contemporary Pediatrics; Sep2019, Vol. 21 Issue 9, p876-880, 5p |
| مصطلحات موضوعية: |
LEUKOCYTE count, MYCOPLASMA pneumoniae, MYCOPLASMA pneumoniae infections, BLOOD sedimentation, LACTATE dehydrogenase |
| الملخص (بالإنجليزية): |
Objective To study the correlation of Mycoplasma pneumoniae DNA (MP-DNA) replication level in throat swab and bronchoalveolar lavage fluid (BALF) with disease severity in children with severe Mycoplasma pneumoniae pneumonia (SMPP). Methods A total of 44 children with SMPP who underwent bronchoalveolar lavage were enrolled as subjects. The serum levels of cytokines and MP-DNA replication times in throat swab were measured in the acute stage and the recovery stage, and the levels of interleukin (IL)-8 and MP-DNA replication times in BALF were measured in the acute stage. According to whether mechanical ventilation was needed for respiratory failure, the children were divided into a mechanical ventilation group (n=19) and a non-mechanical ventilation group (n=25), and the two groups were compared in MP-DNA replication times in BALF. Results For the children with SMPP, serum levels of C-reactive protein, erythrocyte sedimentation rate, lactate dehydrogenase, IL-1, IL-6, IL-8, and IL-18 in the acute stage were significantly higher than those in the recovery stage (P<0.05). In the acute stage, MP-DNA replication times in throat swab were positively correlated with those in BALF (r=0.613, P<0.05), and MP-DNA replication times in BALF were positively correlated with IL-18 levels in peripheral blood and BALF (r=0.613 and 0.41 respectively, P<0.05). Compared with the non-mechanical ventilation group, the mechanical ventilation group had significantly higher MP-DNA replication times in BALF, a significantly longer duration of systemic hormone treatment, significantly higher serum levels of lactate dehydrogenase and IL-18, and significantly higher white blood cell count and IL-18 level in BALF (P<0.05). Conclusions In children with SMPP, MP-DNA replication level in throat swab and BALF can be used as a reference index for the assessment of disease severity. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的 探讨重症肺炎支原体肺炎（SMPP）患儿咽拭子、肺泡灌洗液（BALF）中肺炎支原体 DNA（MP-DNA）复制水平与病情的相关性。方法 44 例行支气管肺泡灌洗术的SMPP 患儿为研究对象, 分别 在急性期和恢复期检测相关血清细胞因子水平及咽拭子MP-DNA 复制倍数, 并检测急性期BALF 中白细胞介素 （IL）-18 水平及MP-DNA 复制倍数。并按照病程中是否出现呼吸衰竭需要机械通气分为机械通气组（n=19） 与非机械通气组（n=25）, 比较两组患儿肺泡灌洗液中MP-DNA 复制倍数。结果 与恢复期相比, SMPP 患儿 在急性期时, 血清C 反应蛋白、红细胞沉降率、乳酸脱氢酶、IL-1、IL-6、IL-8、IL-18 水平显著增高（P<0.05）。 急性期咽拭子与BALF 的MP-DNA 复制倍数呈显著正相关（r=0.613, P<0.05）；BALF 中MP-DNA 复制倍数与 外周血及BALF 的IL-18 水平呈正相关（分别r=0.613、0.41, 均P<0.05）。机械通气组BALF 中MP-DNA 复 制倍数高于非机械通气组, 且全身激素治疗时间明显长于非机械通气组, 血清乳酸脱氢酶、IL-18 及BALF 中 WBC 总数、IL-18 水平也更高（P<0.05）。结论 SMPP 患儿急性期咽拭子与BALF MP-DNA 复制水平可作为病 情评估的参考。. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
