دورية أكاديمية
Effects of genetic polymorphism of CYP3A4 and CYP3A5 on analgesic efficacy of postoperative intravenous analgesia with sufentanil in patients after laparoscopic surgery
| العنوان: | Effects of genetic polymorphism of CYP3A4 and CYP3A5 on analgesic efficacy of postoperative intravenous analgesia with sufentanil in patients after laparoscopic surgery |
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| المؤلفون: | GU Li, ZHOU Li, LI Yongshuai, FENG Liyuan, CHEN Xingtong |
| المصدر: | Di-san junyi daxue xuebao, Vol 44, Iss 9, Pp 930-934 (2022) |
| بيانات النشر: | Editorial Office of Journal of Third Military Medical University, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | cyp3a4, cyp3a5, genetic polymorphism, sufentanil, self-control analgesia, Medicine (General), R5-920 |
| الوصف: | Objective To explore the differences of postoperative patient-controlled intravenous analgesia (PCIA) with sufentanil in the patients with different CYP3A4 and CYP3A5 genotypes after laparoscopic surgery. Methods According to CYP3A4 and CYP3A5 genotypes, the population are divided into class Ⅰ (CYP3A4 homozygous mutation, or CYP3A4 heterozygous mutation combined with CYP3A5 homozygous mutation), class Ⅱ (CYP3A4 heterozygous mutation combined with CYP3A5 heterozygous mutation), and class Ⅲ (CYP3A4 wild type, or CYP3A4 heterozygous mutation combined with CYP3A5 wild type). The patients undergoing laparoscopic surgeries in the departments of general surgery and urology of our first affiliated hospital from November 2020 to September 2021 were included in this prospective observational study. Oral swabs were collected for gene detection on CYP3A4 and CYP3A5 during the pre-anesthesia evaluation. According to their genotypes and 1 ∶1 ratio of men and women, they were randomly divided into group A, B and C by the randomized envelope and blind methods, with 30 patients in each group. The gene types of each group would be revealed through 2 steps. All patients in 3 groups received postoperative intravenous analgesia with sufentanil. The data, at 12, 24 and 48 h after surgery were collected as the following: visual analog analgesia score (VAS), Ramsay sedation score, cumulative dose of sufentanil, numbers of analgesic pump compressions, and incidence of postoperative nausea and vomiting. Results A total of 256 oral swab specimens were collected, and 23, 24, and 27 patients in group A, B and C completed the study respectively. After data collection and statistical analysis, the genotype types of the patients in groups A, B and C were disclosed, corresponding to class Ⅰ, Ⅱ and Ⅲ populations respectively. Compared with class Ⅰ, the Ramsay score was significantly increased at 12 h after surgery in the patients from class Ⅲ (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 2097-0927 1000-5404 |
| العلاقة: | http://aammt.tmmu.edu.cn/Upload/rhtml/202110037.htmTest; https://doaj.org/toc/1000-5404Test |
| DOI: | 10.16016/j.2097-0927.202110037 |
| الوصول الحر: | https://doaj.org/article/35a5e43234c640fab3a58978b2271b72Test |
| رقم الانضمام: | edsdoj.35a5e43234c640fab3a58978b2271b72 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20970927 10005404 |
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| DOI: | 10.16016/j.2097-0927.202110037 |