دورية أكاديمية
Indirect Spectrofluorometric Determination of Enoxaparin Sodium in Pharmaceutical Formulation (Injection) by Ion Association Complex Formation with Acriflavine Dye
| العنوان: | Indirect Spectrofluorometric Determination of Enoxaparin Sodium in Pharmaceutical Formulation (Injection) by Ion Association Complex Formation with Acriflavine Dye |
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| المؤلفون: | mohamed aghwan, Elham Al-talibi |
| المصدر: | مجلة التربية والعلم, Vol 29, Iss 2, Pp 45-62 (2020) |
| بيانات النشر: | College of Education for Pure Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Education LCC:Science (General) |
| مصطلحات موضوعية: | spectrofluorometry, ،,؛acriflavine dye, ،,؛enoxaparin sodium, ،,؛ion association complex, Education, Science (General), Q1-390 |
| الوصف: | A simple, sensitive and selective spectrofluorometric method has been developed for the determination of enoxaparin sodium in bulk and dosage forms (injection). The method was based on the quantitative quenching effect of enoxaparin on the native fluorescence of acriflavine due to the formation of nonfluorescent supramolecular ion issociation complex between the studied drug and acriflavine dye in aqueous solution. The decrease of acriflavine fluorescence was observed at 506 nm after excitation at 402 nm. The relationship between quenching fluorescence intensity and concentration of enoxaparin sodium was linear in the range 0.05-20 µg/ml and with correlation coefficient 0.9990 and with LOD and LOQ 0.011 and 0.035 µg/ml respectively. The average recovery was 100.51% and RSD is less than 3.23%. The stoichiometry of enoxaparin to acriflavine was calculated a 1:4. The method was applied successfully to the determination of enoxaparin form injection samples and the results were in a good agreement with certified value and standard addition procedure. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Arabic English |
| تدمد: | 1812-125X 2664-2530 |
| العلاقة: | https://edusj.mosuljournals.com/article_164379_abfeb6d8c443f4772200398bc25242ce.pdfTest; https://doaj.org/toc/1812-125XTest; https://doaj.org/toc/2664-2530Test |
| DOI: | 10.33899/edusj.2019.125843.1001 |
| الوصول الحر: | https://doaj.org/article/0430f70844e8453cbfa636391c145eefTest |
| رقم الانضمام: | edsdoj.0430f70844e8453cbfa636391c145eef |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 1812125X 26642530 |
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| DOI: | 10.33899/edusj.2019.125843.1001 |