التفاصيل البيبلوغرافية
| العنوان: |
Ex-vivo assessment of meningococcal resistance to natural immunity: serum bactericidal assays versus whole- blood assay. |
| المؤلفون: |
Nejad, Zahra Eslami1, Nafs, Nikoo Nik2, Adeli, Nosratollah Saeed1 |
| المصدر: |
Journal of Mazandaran University of Medical Sciences (JMUMS). 2009, Vol. 18 Issue 68, p48-57. 10p. |
| مصطلحات موضوعية: |
*CEREBROSPINAL meningitis, *NATURAL immunity, *ANTI-infective agents, *BLOOD lipids, *ISOPENTENOIDS, *BODY mass index, *OBESITY in women, *WOMEN'S health, *MEDICAL research |
| مستخلص: |
Background and purpose: Literature review indicates that antibiotic resistance of bacteria may be associated with the resistance to host natural immunity. In the previous study we found that: all meningococcal isolates of meningitis cases are less sensitive to typical anti-meningococcal antibiotics. In present study, the association of the above characters was analyzed in an ex-vivo "case-control" study. Materials and methods: A randomized controlled trial compared effect two dietary treatments (low glycemic index & low fat) in 46 adults, ages 18-55 years old, BMI >27,who proceed to motahary clinic in shiraz, Iran. Body weight, BMI, WHR (waist/hip ratio), fast and post-prandial Plasma lipid profile (Triacylglycerol, total Cholesterol, LDL-C, HDL-C concentration) level of obese women measured at the beginning and at the end 6 weeks. Results: The resistance of both groups against selected sera were similar in the ratio 1:2- by SIC and SBC methods. The growth of "test" and "control" groups in the pooled sera were stopped at the ratios 1:512 and 1:1024 respectively. In SBA the population of "test" and "control" groups decreased in parallel to each other. However, the invasive (test) meningococcal strains established slower reduction in WBA. Conclusion: Studies on the correlation between antibiotic resistance of bacteria and the resistance to the natural immunity have ended with different results. According to our experience, it seems that for ex- vivo investigation of natural immunity against meningococci the WBA is more reliable. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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