Interleukin-1 Receptor Antagonist (IL-1RN) Gene Variable Number Tandem Repeats (VNTR) Polymorphism Association in men Infertility in Erbil City /Kurdistan Iraq
| العنوان: | Interleukin-1 Receptor Antagonist (IL-1RN) Gene Variable Number Tandem Repeats (VNTR) Polymorphism Association in men Infertility in Erbil City /Kurdistan Iraq |
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| المؤلفون: | Ahmed Abdulqader Al-Naqshbandi, Yassin Kareem Amin, Saeed Ghulam, Ashti Mohammad Amin Said |
| المصدر: | Baghdad Science Journal, Vol 18, Iss 3 (2021) |
| بيانات النشر: | College of Science for Women, University of Baghdad, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Infertility, 030219 obstetrics & reproductive medicine, General Computer Science, General Mathematics, Science, General Physics and Astronomy, General Chemistry, Biology, medicine.disease, Agricultural and Biological Sciences (miscellaneous), Molecular biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Variable number tandem repeat, 030104 developmental biology, 0302 clinical medicine, Interleukin 1 receptor antagonist, medicine, Vntr polymorphism |
| الوصف: | The interleukin-1 family has multifaceted roles in men٫s reproductive syste. Out of these is interleukin-1 receptor antagonist (IL-1RN) which exists in men gonads, and in case of infection and inflammatory process, its activity is increased. The current study aims to verify a possible linkage of Variable Number Tandem Repeat (VNTR) polymorphism of the IL-1RN gene with human men infertility. The study groups enrolled included 100 infertile men and 100 fertile and healthy men. Their seminal fluids were subjected to analysis. Also peripheral blood samples were collected for the assessment or detection of polymorphic Variable Number Tandem Repeats (VNTR) polymorphism of interleukin-1 receptor antagonist gene (IL-1RN). Two alleles, namely IL-1RN1 allele corresponding to 410bp fragment and IL-11RN2 that corresponding to 240bp fragments, are a marker for human men infertility, detected by PCR technique. The results delineated a high frequency of IL-1RN2 allelic gene variants (26%), and two VNTR allelic gene variants carriers IL-1RN1 and IL-1RN2 (16%) among infertile men with significant impacts on sperm motility and morphology (P< 0.000-0.002) respectively. This prospective study inKurdistan region (Erbil –Iraq) defined a significant impact of VNTR polymorphism of IL-1RN gene in the etiology of men infertility especially on sperm motility and morphology; particularly carriers of IL-1RN2 allelic variants |
| اللغة: | Arabic |
| تدمد: | 2411-7986 2078-8665 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ad9ccae9b80fb289d1c302969efce8Test https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3856Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b0ad9ccae9b80fb289d1c302969efce8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24117986 20788665 |
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