| الوصف: |
Background Serum alanine transaminase (ALT) and aspartate aminotransferase (AST) are common liver enzymes, but there are few studies on the correlation of these enzymes with the prevalence of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS) . Objective To explore the association of serum ALT and AST/ALT ratio with T2DM and MS in older physical examinees in the community. Methods From January to December, 2018, 30 060 elderly people (≥65 years) who underwent free physical examination in 19 community health centers of 6 districts in Wuhan were chosen as the subjects. Their demographic data, life style, previous medical history, and results of physical examination and biochemical test were collected. Subjects were divided into quartile groups of ALT〔Q1 (ALT≤11 U/L, n=8 116), Q2 (11 U/L19 U/L, n=7 498) 〕, or quartile groups of AST/ALT ratio〔q1 (AST/ALT≤1.06, n=7 386), q2 (1.061.62, n=7 447) 〕. Cochran χ2 test was used to compare the prevalence trend of T2DM, MS, abdominal obesity, hypertension, elevated triglycerides (TG) and lowered high-density lipoprotein cholesterol (HDL-C) with the change of ALT level and AST/ALT ratio. Multivariate Logistic regression analysis was used to explore the correlation of prevalence of T2DM and MS with ALT level and AST/ALT ratio. Results The age of 30 060 subjects (13 381 men and 16 679 women) was 65-99 years old, and the average age was (71.7±5.6) years old. The prevalence of T2DM and MS was 18.76% (5 488/30 060) and 29.73% (8 938/30 060), respectively. The regular exercise rate, BMI, waist circumference, systolic pressure, diastolic pressure, ALT, TG and fasting plasma glucose (FPG) were significantly higher and smoking rate, drinking rate, AST, AST/ALT ratio, total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C) were significantly lower in T2DM subjects compared to non-T2DM subjects (P |
