Low-molecular-weight heparin has multiple advantages of high bioavailability, long half-life, few side effects and convenient use, which has been widely applied in the prevention of lower limb venous thrombosis after gynecologic tumor surgery. However, in clinical practice, partial patients present with subcutaneous ecchymosis induced by drug use. Most of them can regress spontaneously after terminating drug use. In this article, a 49-year-old female patient, who was diagnosed with cervical cancer, developed severe skin necrosis and secondary sinus formation caused by use of low-molecular-weight heparin after cervical cancer surgery. She was diagnosed with cervical cancer（IB3 FIGO stage G2）, and treated with enoxaparin sodium injection for 14 d because of deep venous thrombosis of the lower limbs. At 1 month after withdrawal of drug use, she presented with plaque mass in the lower abdomen. The possibility of skin necrosis was considered, which was cured by the ostomyist for 7 months. This case prompts that the risk of skin necrosis should be considered during use of enoxaparin.
