التفاصيل البيبلوغرافية
| العنوان: |
Postoperative Hepatic Catabolic Stress Response in Patients with Cirrhosis and Chronic Hepatitis. |
| المؤلفون: |
Lausten, Susanne B., El-Sefi, Talaat, Marwan, Ibrahim, Ibrahim, Tarek M., Jensen, Lone S., Grøfte, Thorbjørn, Andreasen, Frederik, Vilstrup, Hendrik, Raouf, Ahmed A., Helmy, Amr, Jensen, Steen L. |
| المصدر: |
World Journal of Surgery; Mar2000, Vol. 24 Issue 3, p365-371, 7p |
| مستخلص: |
Open (OC) or laparoscopic (LC) cholecystectomy is considered a relative contraindication in patients with liver cirrhosis. The effect of LC and OC on the hepatic catabolic stress response was studied in patients with postnecrotic liver cirrhosis and chronic hepatitis to define the most suitable procedure from a metabolic point of view. Altogether 14 patients with cirrhosis and 14 with chronic hepatitis were randomized to LC or OC ( n= 7 in each group). The increase in the functional hepatic nitrogen clearance (FHNC) was quantified. Changes in glucose, insulin, glucagon, cortisol, epinephrine, norepinephrine, and prostaglandin E2 (PGE2) were observed. There was no difference in FHNC between LC and OC in any of the patients. Among cirrhotic patients OC caused a 132% increase in FHNC ( p < 0.05) and among the hepatitis patients a 69% increase ( p < 0.05). In contrast, there was no significant increase following LC in any of the patients. OC increased fasting glucose and insulin in the hepatitis patients ( p < 0.01 and p < 0.001, respectively) and in the cirrhosis group ( p < 0.01 and p < 0.05, respectively). Alanine stimulation increased glucose in hepatitis patients after OC ( p < 0.05) and after LC ( p < 0.01). Stimulated glucagon increased after OC in the hepatitis group ( p < 0.05). During stimulation cortisol was higher following LC in hepatitis patients ( p < 0.01) and cirrhotic patients ( p < 0.05). Fasting PGE2 was down-regulated after LC in hepatitis patients ( p < 0.05) and cirrhotic patients ( p < 0.01) and after OC in the hepatitis group ( p < 0.001). FHNC is similar after LC and OC. Thus from a metabolic point of view, LC has no advantage over OC. [ABSTRACT FROM AUTHOR] |
|
Copyright of World Journal of Surgery is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
