المؤلفون: Seok Byung Lim, Jun Ho Lee, Jin Cheon Kim, Jong Lyul Lee, In Ja Park, Chang Sik Yu

المصدر: World journal of surgery. 41(4)

مصطلحات موضوعية: Oncology, Adult, Male, medicine.medical_specialty, Lymphovascular invasion, Colorectal cancer, Familial adenomatous polyposis, 03 medical and health sciences, 0302 clinical medicine, Carcinoembryonic antigen, Risk Factors, Internal medicine, medicine, Humans, Aged, Neoplasm Staging, Retrospective Studies, biology, business.industry, Rectal Neoplasms, Hazard ratio, Retrospective cohort study, Middle Aged, medicine.disease, Prognosis, Carcinoembryonic Antigen, Cardiothoracic surgery, 030220 oncology & carcinogenesis, biology.protein, 030211 gastroenterology & hepatology, Surgery, Female, Lymph Nodes, Neoplasm Recurrence, Local, business, Colorectal Neoplasms, Abdominal surgery

الوصف: Patients with stage I colorectal cancer (CRC) rarely experience recurrences; therefore, few risk factors for recurrence are known. This study was designed to evaluate oncologic outcomes of patients with stage I CRC and to identify risk factors for recurrence after curative surgery. A retrospective cohort of 860 patients from a single institution who underwent curative surgery for stage I CRC between July 1995 and June 2010 was enrolled. Patients who were diagnosed with hereditary, synchronous, or metachronous cancer and those who received preoperative chemoradiotherapy were excluded. Patients from whom fewer than 12 lymph nodes were retrieved were also excluded. The 860 patients included 402 (46.7%) with colon tumors and 458 (53.3%) with rectal tumors. Thirty-five patients (4.1%) experienced recurrences; local and systemic recurrence rates were 1.1 and 3.0%, respectively. The 5-year overall survival and recurrence-free survival (RFS) rates were 93.5 ± 0.8% and 95.7 ± 0.8%, respectively. Multivariate analysis showed that preoperative serum carcinoembryonic antigen (CEA) concentration ≥6 ng/mL (hazard ratio [HR] 3.354, 95% confidence interval [CI] 1.373–8.195, p = 0.008) and lymphovascular invasion (LVI) (HR 2.676, 95% CI 1.097–6.531, p = 0.031) were independent risk factors for RFS. The overall recurrence rate among patients with stage I CRC after curative surgery was 4.1%. Elevated serum CEA and LVI were significantly associated with recurrence. Large-scale, multicenter studies are needed to confirm the prognostic value of these risk factors.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e41e4c20d6f6cd42ad2e11c3852624Test
https://pubmed.ncbi.nlm.nih.gov/28321557Test

المؤلفون: Jun Ho Lee, Jong Lyul Lee, Jin Cheon Kim

المصدر: World Journal of Surgery. 41:1658-1659

مصطلحات موضوعية: 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Colonic Neoplasms, Humans, Surgery, Neoplasm Recurrence, Local, 030230 surgery, Colorectal Neoplasms, Prognosis, Neoplasm Staging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd81de9df37825dbe16d7409092839f1Test
https://doi.org/10.1007/s00268-017-3994-7Test

المؤلفون: Sang Nam Yoon, Jin Cheon Kim, Seok-Byung Lim, Chang Sik Yu, Yong Sik Yoon, Song-Soo Yang

المصدر: World Journal of Surgery. 35:881-887

مصطلحات موضوعية: Male, medicine.medical_specialty, Databases, Factual, Deep vein, Venography, Intermittent pneumatic compression, Risk Assessment, Cohort Studies, Age Distribution, Postoperative Complications, Confidence Intervals, Humans, Medicine, Hospital Mortality, cardiovascular diseases, Sex Distribution, Aged, Retrospective Studies, Venous Thrombosis, Analysis of Variance, Korea, medicine.diagnostic_test, Heparin, business.industry, Incidence, Anticoagulants, Cancer, Postoperative complication, Middle Aged, equipment and supplies, medicine.disease, Survival Analysis, Surgery, Pulmonary embolism, Venous thrombosis, Logistic Models, medicine.anatomical_structure, Multivariate Analysis, Female, Colorectal Neoplasms, Pulmonary Embolism, business, Colorectal Surgery, Stockings, Compression, Abdominal surgery

الوصف: The occurrence of venous thromboembolism (VTE), manifesting as deep vein thrombosis (DVT) or pulmonary embolism (PE), after colorectal cancer surgery in Asian patients remains poorly characterized. The present study was designed to investigate the incidence of symptomatic VTE in Korean colorectal cancer patients following surgery, and to identify the associated risk factors. We retrospectively analyzed data from patients who developed symptomatic VTE after colorectal cancer surgery between 2006 and 2008. Deep vein thrombosis was diagnosed with Doppler ultrasound or contrast venography, and PE was identified with lung ventilation/perfusion scans or chest computed tomography. Thromboprophylaxis, including low-molecular-weight heparin, graduated compression stockings, and intermittent pneumatic compression, was used in patients considered at high risk of VTE. Of the 3,645 patients who underwent colorectal cancer surgery, 31 (0.85%) developed symptomatic VTE. Of those 31 patients, 23 (74.2%) had DVT, 16 (51.6%) had PE, and 8 (25.8%) had both. Two patients died from PE. Univariate analysis showed that a history of VTE, pre-existing cardiovascular disease, respiratory disease, transfusions, postoperative immobilization time, and postoperative complications were associated with VTE (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59e41d5ed3b1950eb7f0237dcfb53a2Test
https://doi.org/10.1007/s00268-011-0957-2Test

المؤلفون: Jae Seung Kim, Hyun Kwon Ha, Hye Jin Kim, Jae Young Kwak, Jin Cheon Kim, Chang Sik Yu

المصدر: World journal of surgery. 36(8)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Colorectal cancer, Lymph node metastasis, Multimodal Imaging, Sensitivity and Specificity, Fluorodeoxyglucose F18, Predictive Value of Tests, Image Interpretation, Computer-Assisted, medicine, Humans, Lymph node, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, Chi-Square Distribution, medicine.diagnostic_test, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Prognosis, medicine.anatomical_structure, Positron emission tomography, Cardiothoracic surgery, Predictive value of tests, Lymphatic Metastasis, Positron-Emission Tomography, Surgery, Female, Radiology, Tomography, Radiopharmaceuticals, business, Colorectal Neoplasms, Tomography, X-Ray Computed

الوصف: Lymph node metastasis is an important prognostic factor in patients with colorectal cancer. We assessed the ability of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to diagnose lymph node metastases in colorectal cancer patients.We retrospectively analyzed the records of 473 patients who underwent preoperative FDG-PET/CT, followed by curative surgery for colorectal cancer. Lymph node metastases were assessed as proximal or distal, depending on their anatomical location. We analyzed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG-PET/CT and CT for detecting lymph node metastases.In detecting proximal lymph nodes, FDG-PET/CT had a sensitivity of 66 %, a specificity of 60 %, a PPV of 63 %, an NPV of 62 %, and an accuracy of 63 %; whereas CT had a sensitivity of 87 %, a specificity of 29 %, a PPV of 57 %, an NPV of 68 %, and an accuracy of 59 % (P = 0.245). FDG-PET/CT and CT also showed similar accuracy in detecting distal lymph nodes (87 vs. 88 %, P = 0.620).Preoperative FDG-PET/CT and CT have comparable accuracy in detecting lymph node metastases of colorectal cancer.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d80753b7d7b91fe5da59a0928efca46Test
https://pubmed.ncbi.nlm.nih.gov/22526032Test

المؤلفون: Sung Tae Oh, Seok-Byung Lim, Jong Hoon Kim, Tae Won Kim, Jin Cheon Kim, Chang Sik Yu, Sang Nam Yoon

المصدر: World journal of surgery. 34(9)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Colorectal cancer, Lymphovascular invasion, Gastroenterology, Disease-Free Survival, Neoplasms, Multiple Primary, Stomach Neoplasms, Internal medicine, medicine, Humans, Neoplasm Invasiveness, Stomach cancer, Aged, Neoplasm Staging, Univariate analysis, business.industry, Cancer, Neoplasms, Second Primary, Odds ratio, Middle Aged, medicine.disease, Prognosis, digestive system diseases, Carcinoembryonic Antigen, Standardized mortality ratio, MSH2, Multivariate Analysis, Surgery, Female, Microsatellite Instability, business, Colorectal Neoplasms

الوصف: We investigated the characteristics of synchronous and metachronous gastric cancer in patients with colorectal cancer. We reviewed 8,680 patients who underwent operations for primary sporadic colorectal cancer from 1989 to 2008. Synchronous gastric cancer was defined as gastric cancer diagnosed within 6 months of a colorectal cancer diagnosis. Gastric cancer diagnosed more than 6 months before or after colorectal cancer was defined as metachronous. The incidences of synchronous and metachronous gastric cancer were 0.93 and 1.4%, respectively (combined 2.4%). The standardized incidence ratio was 1.199 (95% confidence interval [CI] = 1.005–1.420) when the patients with premetachronous gastric cancer were excluded. Patients with synchronous and metachronous gastric cancer were 5 years older on average compared to the control population without gastric cancer. In addition, multivariate analysis revealed an odds ratio (OR) of 3.6 for being male, OR = 2 for positive family history of solid tumors, OR = 2.2 for colonic lesion, and OR = 4 for MSH2 expression loss compared to patients without gastric cancer. Patients with postmetachronous gastric cancer (when compared to synchronous and premetachronous gastric cancer), a preoperative CEA level of less than 6 ng/ml, and a relatively early stage of colorectal cancer had significantly higher overall (p = 0.016, 0.007, and 0.004, respectively) and disease-free survival rates (p = 0.046, 0.003, and 0.004, respectively), only on univariate analysis. Lymphovascular invasion of colorectal cancer and an advanced stage of gastric cancer were independent poor prognostic factors for both overall (p = 0.018) and disease-free survival (p = 0.028). Gastric cancer surveillance is recommended for patients with colorectal cancer, especially when the patient is old and male, has a positive family history of solid tumors, has a colonic lesion, or lacks MSH2 expression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d179e4879e7f1b32d4259ae7b0c735ecTest
https://pubmed.ncbi.nlm.nih.gov/21088835Test