Chronological Improvement in Survival Following Rectal Cancer Surgery: A Large-Scale, Single-Center Study
| العنوان: | Chronological Improvement in Survival Following Rectal Cancer Surgery: A Large-Scale, Single-Center Study |
|---|---|
| المؤلفون: | Chang Sik Yu, Yong Sik Yoon, Seok-Byung Lim, Jong Lyul Lee, Chang Wook Kim, Jin Cheon Kim |
| المصدر: | World Journal of Surgery. 37:2693-2699 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Colorectal cancer, Single Center, medicine, Humans, Neoplasm Staging, Retrospective Studies, Rectal Neoplasms, business.industry, Middle Aged, Vascular surgery, medicine.disease, Combined Modality Therapy, Total mesorectal excision, Surgery, Cardiac surgery, Survival Rate, Treatment Outcome, Chemotherapy, Adjuvant, Cardiothoracic surgery, Rectal cancer surgery, Radiotherapy, Adjuvant, Female, sense organs, Neoplasm Recurrence, Local, business, Abdominal surgery |
| الوصف: | Total mesorectal excision (TME) and preoperative chemoradiation therapy (PCRT) for rectal cancer are used sequentially in our center. The aim of this study was to evaluate survival of patients with stage II/III rectal cancer chronologically and to determine whether therapeutic advances associated with TME and PCRT have improved patient survival.A retrospective review of 2,197 patients from July 1989 to December 2006 was conducted. The time period (P) for this study was divided into three groups: P1 (1989-1995), P2 (1996-2001) for TME, P3 (2002-2006) for PCRT. Cancer-specific survival (CSS), disease-free survival (DFS), and recurrences among the three periods were investigated.A total of 293 patients in P1, 836 patients in P2, and 1,068 patients in P3 were enrolled. The 5-year CSS in stages II and III was statistically different between P1/P2 and P3 (stage II, p = 0.008; stage III, p0.001). The 5-year DFS was significantly different between P1/P2 and P3 for stage III (p = 0.001). The local recurrence and systemic recurrence rates decreased during P3, but there was no significant difference between the three periods for stage II. For stage III, local recurrence was significantly different between the three periods (P1 vs. P2, p = 0.002; P1 vs. P3, p0.001; P2 vs. P3, p = 0.008).We identified an improvement in survival for stage II/III rectal cancer and a decrease in local recurrence for stage III rectal cancer during P3, the most recent period. This may be due to frequent application of PCRT based on the TME. |
| تدمد: | 1432-2323 0364-2313 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08726cc817d31d08197f115d1f999ba7Test https://doi.org/10.1007/s00268-013-2168-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....08726cc817d31d08197f115d1f999ba7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322323 03642313 |
|---|