التفاصيل البيبلوغرافية
| العنوان: |
Family history of alcohol dependence and gray matter abnormalities in non-alcoholic adults. |
| المؤلفون: |
Sjoerds, Zsuzsika, Van Tol, Marie-José, van den Brink, Wim, Van der Wee, Nic J.A., Van Buchem, Mark A., Aleman, André, Penninx, Brenda W.J.H., Veltman, Dick J. |
| المصدر: |
World Journal of Biological Psychiatry; Dec2013, Vol. 14 Issue 8, p565-573, 9p |
| مصطلحات موضوعية: |
ALCOHOLISM, PSYCHIATRIC research, CHILD psychology, MENTAL health, ANXIETY |
| مستخلص: |
Objectives. Alcohol-use disorders in adolescents are associated with gray matter (GM) abnormalities suggesting neurotoxicity by alcohol. However, recently similar GM abnormalities were found in non-drinking children with a family history (FH) of alcohol dependence (AD). The question thus rises whether these abnormalities represent a transient delay in brain maturation or a persistent risk factor for developing neuropsychiatric disorders, rather than a (neurotoxic) consequence of AD. This study investigated whether a FH of AD in non-drinking adults is associated with abnormal GM-volumes similar to those observed in drinking and non-drinking adolescents with a FH of AD. Methods. GM-images were analyzed using Voxel-Based Morphometry in non-alcoholics with (FH+; N = 36) and without (FH-; N = 107) familial AD. Additionally we controlled for possible confounders: diagnosis of depression/anxiety, childhood trauma and familial depression/anxiety. Results. Smaller GM-volumes were shown in the right parahippocampal gyrus in FH+ compared with FH-. Results were unaffected by confounders. Conclusions. We demonstrated an effect of familial AD in non-alcoholic adults on GM volume in the parahippocampal gyrus, similar to drinking and non-drinking FH+ adolescents. These findings suggest that GM abnormalities in the parahippocampal gyrus represent a persistent biological susceptibility for AD or related psychopathology and not neurotoxicity of alcohol or delayed brain maturation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
