التفاصيل البيبلوغرافية
| العنوان: |
Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma. |
| المؤلفون: |
Kameda, Takuro, Shide, Kotaro, Tahira, Yuki, Sekine, Masaaki, Sato, Seiichi, Ishizaki, Junzo, Takeuchi, Masanori, Akizuki, Keiichi, Kamiunten, Ayako, Shimoda, Haruko, Toyama, Takanori, Maeda, Kouichi, Yamashita, Kiyoshi, Kawano, Noriaki, Kawano, Hiroshi, Hidaka, Tomonori, Yamaguchi, Hideki, Kubuki, Yoko, Kitanaka, Akira, Matsuoka, Hitoshi |
| المصدر: |
Viruses (1999-4915); Apr2022, Vol. 14 Issue 4, pN.PAG-N.PAG, 9p |
| مصطلحات موضوعية: |
ADULT T-cell leukemia, LYMPHOMAS, BLOOD urea nitrogen, SURVIVAL rate, PROGNOSIS |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
A retrospective chart survey of the clinical features of indolent adult T-cell leukemia/lymphoma (ATL) was conducted in the Miyazaki Prefecture, Japan. This study enrolled 24 smoldering-type ATLs, 10 favorable chronic-type ATLs, and 20 unfavorable chronic-type ATLs diagnosed between 2010 and 2018. Among them, 4, 3, and 10 progressed to acute-type ATLs during their clinical course. The median survival time (MST) in smoldering-type ATL and favorable chronic-type ATL was not reached, and their 4-year overall survival (OS) was 73% and 79%, respectively. Compared with this, the prognosis of unfavorable chronic-type ATL was poor. Its MST was 3.32 years, and the 4-year OS was 46% (p = 0.0095). In addition to the three features that determine the unfavorable characteristics of chronic-type ATL, namely, increased lactate dehydrogenase, increased blood urea nitrogen, and decreased albumin, the high-risk category by the indolent ATL-Prognostic Index, which was defined by an increment of soluble interleukin-2 receptor (sIL2-R) of >6000 U/mL, could explain the poor prognosis in indolent ATL patients. The level of sIL-2R might be an indicator of the initiation of therapy for indolent ATL. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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