Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells
| العنوان: | Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells |
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| المؤلفون: | Xiaoyong Bao, Thangam Sudha Velayutham, Deepthi Kolli, Dana L. Esham, Antonella Casola |
| المصدر: | Viruses; Volume 10; Issue 6; Pages: 278 Viruses, Vol 10, Iss 6, p 278 (2018) Viruses |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, SH protein, viruses, Retroviridae Proteins, Oncogenic, lcsh:QR1-502, Recombinant virus, Article, lcsh:Microbiology, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Human metapneumovirus, Interferon, Virology, medicine, Humans, Metapneumovirus, Innate immune system, biology, Chemistry, virus diseases, hemic and immune systems, Dendritic Cells, TLR7, biology.organism_classification, Immunity, Innate, 3. Good health, HEK293 Cells, 030104 developmental biology, Infectious Diseases, Toll-Like Receptor 7, plasmacytoid dendritic cells, Interferon Type I, Myeloid Differentiation Factor 88, hMPV, Signal transduction, type I IFN, Interferon type I, Signal Transduction, 030215 immunology, medicine.drug |
| الوصف: | Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses. |
| وصف الملف: | application/pdf |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84046f20a74119d58c2f4ce973b3278Test https://doi.org/10.3390/v10060278Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e84046f20a74119d58c2f4ce973b3278 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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