Treatment with Class A CpG Oligodeoxynucleotides in Cats with Naturally Occurring Feline Parvovirus Infection: A Prospective Study
| العنوان: | Treatment with Class A CpG Oligodeoxynucleotides in Cats with Naturally Occurring Feline Parvovirus Infection: A Prospective Study |
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| المؤلفون: | Barbara Contiero, Luigi Michele Coppola, Filippo Ferri, Chiara Crinò, Francesco Rossi, Neda Ranjbar Kohan, Regina Hofmann-Lehmann, Gabriele Gerardi, Daniela Enache, Carolina Callegari, Hans Lutz, Federico Porporato, Eric Zini, Marina L. Meli |
| المساهمون: | University of Zurich, Ferri, Filippo |
| المصدر: | Viruses, Vol 12, Iss 640, p 640 (2020) Viruses Volume 12 Issue 6 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, 10253 Department of Small Animals, Feline Panleukopenia, viruses, lcsh:QR1-502, Cell Count, lcsh:Microbiology, 0403 veterinary science, hemic and lymphatic diseases, Leukocytes, Medicine, Prospective Studies, 11434 Center for Clinical Studies, CATS, Leukopenia, treatment, biology, virus diseases, 04 agricultural and veterinary sciences, antiviral, Infectious Diseases, Oligodeoxyribonucleotides, 11404 Department of Clinical Diagnostics and Services, Female, medicine.symptom, Antibody, feline parvovirus, 040301 veterinary sciences, CpG Oligodeoxynucleotide, cat, 610 Medicine & health, Viremia, macromolecular substances, Placebo, Article, 03 medical and health sciences, Virology, Mx protein, otorhinolaryngologic diseases, Animals, Survival rate, business.industry, 2725 Infectious Diseases, Type I interferon production, medicine.disease, 030104 developmental biology, Immunology, Cats, CpG-A, 2406 Virology, biology.protein, Antiviral, Cat, Feline parvovirus, Treatment, Feline Panleukopenia Virus, business |
| الوصف: | Feline parvovirus (FPV) causes severe gastroenteritis and leukopenia in cats the outcome is poor. Information regarding specific treatments is lacking. Class A CpG oligodeoxynucleotides (CpG-A) are short single-stranded DNAs, stimulating type I interferon production. In cats, CpG-A induced an antiviral response in vivo and inhibited FPV replication in vitro. The aim was to prospectively investigate the effects of CpG-A on survival, clinical score, hematological findings, antiviral response (cytokines), viremia, and fecal shedding (real-time qPCR) in cats naturally infected with FPV. Forty-two FPV-infected cats were randomized to receive 100 µ g/kg of CpG-A (n = 22) or placebo (n = 20) subcutaneously, on admission and after 48 h. Blood and fecal samples were collected on admission, after 1, 3, and 7 days. All 22 cats showed short duration pain during CpG-A injections. The survival rate, clinical score, leukocyte and erythrocyte counts, viremia, and fecal shedding at any time-point did not differ between cats treated with CpG-A (50%) and placebo (40%). Antiviral myxovirus resistance (Mx) gene transcription increased in both groups from day 1 to 3 (p = 0.005). Antibodies against FPV on admission were associated with survival in cats (p = 0.002). In conclusion, CpG-A treatment did not improve the outcome in cats with FPV infection. FPV infection produced an antiviral response. |
| وصف الملف: | application/pdf |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5d5b1f9a25e12a186302e6dda6b8cdTest https://doi.org/10.3390/v12060640Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5f5d5b1f9a25e12a186302e6dda6b8cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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