Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)
| العنوان: | Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3) |
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| المؤلفون: | Xiaole Qi, Qing Pan, Xiaomei Wang, Changjun Liu, Linjin Fan, Yulong Wang, Hongyu Cui, Wenying Zhang, Li Gao, Xinxin Niu, Nan Jiang, Yulong Gao, Mengmeng Huang, Yanping Zhang, Kai Li, Aijing Liu |
| المصدر: | Viruses, Vol 13, Iss 1682, p 1682 (2021) Viruses |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | animal structures, infectious bursal disease virus, Genotype, Reassortment, Virulence, Genome, Viral, Disease, Microbiology, Virus, Infectious bursal disease, Virology, medicine, Animals, pathogenicity, genome, Phylogeny, Poultry Diseases, biology, Brief Report, Strain (biology), RNA virus, Birnaviridae Infections, medicine.disease, biology.organism_classification, QR1-502, Specific Pathogen-Free Organisms, Infectious Diseases, segment reassortment, novel variant strain, Chickens, Reassortant Viruses |
| الوصف: | Infectious bursal disease virus (IBDV) is a non-enveloped, bi-segmented double-stranded RNA virus and the causative agent of a poultry immunosuppressive disease known as infectious bursal disease (IBD). The novel variant IBDV (nVarIBDV) recently posed a great threat to the development of the poultry industry. In this study, we identified a novel segment-reassortant IBDV strain, IBDV-JS19-14701 (Genotype A2dB3). Phylogenic analysis showed that Segments A and B of IBDV-JS19-14701 were derived from emerging nVarIBDV (Genotype A2dB1) and long-prevalent HLJ0504-like strains (Genotype A3B3) in China, respectively. The pathogenicity of IBDV-JS19-14701 was further evaluated via animal experiments. IBDV-JS19-14701 exhibited a similar virulence to chickens with the nVarIBDV. The identification of this reassortment event is beneficial for understanding the epidemiology of nVarIBDV and will contribute to the efficient prevention and control of IBD. |
| اللغة: | English |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149ecf78d99901b88834b7d5ad57b567Test https://www.mdpi.com/1999-4915/13/9/1682Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....149ecf78d99901b88834b7d5ad57b567 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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