A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I
| العنوان: | A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I |
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| المؤلفون: | Yuetsu Tanaka, Reiko Tanaka, Yoshiaki Takahashi, Takuya Miyagi, Marie Kunihiro, Hideki Fujii, Mamoru Shimizu |
| المصدر: | Viruses, Vol 8, Iss 2, p 41 (2016) Viruses Viruses; Volume 8; Issue 2; Pages: 41 |
| بيانات النشر: | MDPI AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_treatment, viruses, Retroviridae Proteins, Oncogenic, lcsh:QR1-502, Passive immunity, Epitope, lcsh:Microbiology, Rats, Sprague-Dawley, Mice, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, HTLV-I, NOG mice, neutralizing monoclonal antibody, envelope gp46, passive immunity, Human T-lymphotropic virus 1, biology, Antibodies, Monoclonal, virus diseases, Leukemia, Infectious Diseases, Female, Adult, medicine.drug_class, Monoclonal antibody, Article, 03 medical and health sciences, Virology, Disease Transmission, Infectious, medicine, Animals, Humans, Immunization, Passive, Gene Products, env, Infant, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, medicine.disease, HTLV-I Infections, Infectious Disease Transmission, Vertical, Rats, Inbred F344, In vitro, Rats, Human T cell leukemia virus, 030104 developmental biology, Immunization, Immunology, 030215 immunology |
| الوصف: | Although the number of human T-cell leukemia virus type-I (HTLV-I)-infected individuals in the world has been estimated at over 10 million, no prophylaxis vaccines against HTLV-I infection are available. In this study, we took a new approach for establishing the basis of protective vaccines against HTLV-I. We show here the potential of a passively administered HTLV-I neutralizing monoclonal antibody of rat origin (LAT-27) that recognizes epitopes consisting of the HTLV-I gp46 amino acids 191–196. LAT-27 completely blocked HTLV-I infection in vitro at a minimum concentration of 5 μg/mL. Neonatal rats born to mother rats pre-infused with LAT-27 were shown to have acquired a large quantity of LAT-27, and these newborns showed complete resistance against intraperitoneal infection with HTLV-I. On the other hand, when humanized immunodeficient mice were pre-infused intravenously with humanized LAT-27 (hu-LAT-27), all the mice completely resisted HTLV-I infection. These results indicate that hu-LAT-27 may have a potential for passive immunization against both horizontal and mother-to-child vertical infection with HTLV-I. 論文 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6467868998d60d4eff1df9d7fca03897Test http://www.mdpi.com/1999-4915/8/2/41Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6467868998d60d4eff1df9d7fca03897 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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