Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects
| العنوان: | Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects |
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| المؤلفون: | Tzong-Hae Lee, Edward L. Murphy, Elizabeth H. Blackburn, Roberta Bruhn, Benjamin Usadi, Jue Lin |
| المصدر: | Viruses, vol 8, iss 8 Viruses Viruses, Vol 8, Iss 8, p 221 (2016) Viruses; Volume 8; Issue 8; Pages: 221 |
| بيانات النشر: | MDPI AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | HTLV, HAM, telomere, Male, 0301 basic medicine, viruses, lcsh:QR1-502, lcsh:Microbiology, 0302 clinical medicine, Proviruses, immune system diseases, hemic and lymphatic diseases, 80 and over, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Aged, 80 and over, Human T-lymphotropic virus 1, biology, Human T-lymphotropic virus 2, virus diseases, Viral Load, Middle Aged, 3. Good health, Infectious Diseases, Real-time polymerase chain reaction, Female, Infection, Viral load, Adult, and over, Microbiology, Peripheral blood mononuclear cell, Article, Virus, 03 medical and health sciences, Clinical Research, Virology, medicine, Humans, Peripheral Neuropathy, Aged, Neurosciences, biology.organism_classification, medicine.disease, HTLV-I Infections, Telomere, 030104 developmental biology, Peripheral neuropathy, HTLV-II Infections, Immunology, 030217 neurology & neurosurgery |
| الوصف: | Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-cell lymphotropic virus type 1 (HTLV-1), 45human T-cell lymphotropic virus type 2 (HTLV-2), and 45 seronegative subjects was selected from the larger HTLV Outcomes Study (HOST) cohort, matched on age, sex and race/ethnicity. Telomere-to-single-copy gene (T/S) ratio (a measure of TL) and HTLV-1 and HTLV-2 proviral loads were measured in peripheral blood mononuclear cells (PBMCs) using quantitative PCR (qPCR). Vibration sensation measured by tuning fork during neurologic examinations performed as part of the HOST study allowed for an assessment of peripheral neuropathy. TL was compared between groups using t-tests, linear and logistic regression. Mean T/S ratio was 1.02 ± 0.16 in HTLV-1, 1.03 ± 0.17 in HTLV-2 and 0.99 ± 0.18 in HTLV seronegative subjects (p = 0.322). TL was not associated with HTLV-1 or -2 proviral load. Shorter TL was significantly associated with impaired vibration sense in the HTLV-2 positive group only. Overall, we found no evidence that telomere length was affected by chronic HTLV-1 and HTLV-2 infection. That TL was only associated with peripheral neuropathy in the HTLV-2-positive group is intriguing, but should be interpreted cautiously. Studies with larger sample size and telomere length measurement in lymphocyte subsets may clarify the relationship between TL and HTLV-infection. |
| وصف الملف: | application/pdf |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a619189461705d649385666f6936f6fTest https://doi.org/10.3390/v8080221Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a619189461705d649385666f6936f6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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