التفاصيل البيبلوغرافية
| العنوان: |
Molecular characterization of new emerging sub-genotype VIIh Newcastle disease viruses in China. |
| المؤلفون: |
Liu, Hualei, Wang, Jingjing, Ge, Shengqiang, Lv, Yan, Li, Yin, Zheng, Dongxia, Zhao, Yunling, Castellan, David, Wang, Zhiliang |
| المصدر: |
Virus Genes; Jun2019, Vol. 55 Issue 3, p314-321, 8p |
| مستخلص: |
Newcastle disease (ND) has been enzootic in China for several decades since the first recognition of the disease in 1946 in China. Continuous surveillance revealed that the sub-genotype VIId Newcastle disease virus (NDV) has been predominantly responsible for most of ND outbreak in China in recent years. But in the present study, three virulent NDVs isolated from poultry in southern China were classified as sub-genotype VIIh, which is highly related to the viruses circulating in some Southeast Asia countries. Continuous isolation of genotype VIIh NDV strains in the region suggests its panzootic potential. This is the first report of the sub-genotype VIIh NDVs in domestic poultry in China. The complete genome length of the three isolates was 15,192 nucleotides, and the motif at the cleavage site of F protein was 112RRRRR/F117 or 112RRRKR/F117, which was typical of virulent NDV. Phylogenetic analysis based on the F gene revealed that the three viruses had close relationship with the sub-genotype VIIh virus isolated from wild bird in 2011 in China. These viruses might have formed a stable lineage in poultry during 2012–2016 and have the potential to cause enzootic in China. Our study revealed the genetic and phylogenetic characteristics of the three sub-genotype VIIh isolates, which could help us to better understand the epidemiological context of these viruses. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
