دورية أكاديمية
Proteome analysis of bronchoalveolar lavage fluids reveals host and fungal proteins highly expressed during invasive pulmonary aspergillosis in mice and humans
| العنوان: | Proteome analysis of bronchoalveolar lavage fluids reveals host and fungal proteins highly expressed during invasive pulmonary aspergillosis in mice and humans |
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| المؤلفون: | Silke Machata, Mario M. Müller, Roland Lehmann, Patricia Sieber, Gianni Panagiotou, Agostinho Carvalho, Cristina Cunha, Katrien Lagrou, Johan Maertens, Hortense Slevogt, Ilse D. Jacobsen |
| المصدر: | Virulence, Vol 11, Iss 1, Pp 1337-1351 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | invasive aspergillosis, fungal pulmonary infection, aspergillus fumigatus, biomarker, proteome analysis, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Invasive pulmonary aspergillosis (IPA) is a severe infection that is difficult to diagnose due to the ubiquitous presence of fungal spores, the underlying diseases of risk patients, and limitations of currently available markers. In this study, we performed a comprehensive liquid chromatography tandem mass spectrometry (LC-MS/MS)-based identification of host and fungal proteins expressed during IPA in mice and humans. The proteomic analysis of bronchoalveolar lavage samples of individual IPA and control cases allowed the description of common host factors that had significantly increased abundance in both infected animals and IPA patients compared to their controls. Although increased levels of these individual host proteins might not be sufficient to distinguish bacterial from fungal infection, a combination of these markers might be beneficial to improve diagnosis. We also identified 16 fungal proteins that were specifically detected during infection and may be valuable candidates for biomarker evaluation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2150-5594 2150-5608 21505594 |
| العلاقة: | https://doaj.org/toc/2150-5594Test; https://doaj.org/toc/2150-5608Test |
| DOI: | 10.1080/21505594.2020.1824960 |
| الوصول الحر: | https://doaj.org/article/5350df04459a440e9ade50dfa1dcae57Test |
| رقم الانضمام: | edsdoj.5350df04459a440e9ade50dfa1dcae57 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21505594 21505608 |
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| DOI: | 10.1080/21505594.2020.1824960 |