High expression of CCL2 in tumor cells and abundant infiltration with CD14 positive macrophages predict early relapse in breast cancer
| العنوان: | High expression of CCL2 in tumor cells and abundant infiltration with CD14 positive macrophages predict early relapse in breast cancer |
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| المؤلفون: | Kristiina Joensuu, Marja Heiskala, Päivi Heikkilä, Marjut Leidenius |
| المساهمون: | II kirurgian klinikka, Department of Surgery, Clinicum, Department of Oncology, University of Helsinki, Department of Pathology, Medicum, HUSLAB, HUS Comprehensive Cancer Center |
| المصدر: | Virchows Archiv. 474:3-12 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Chemokine, Time Factors, Angiogenesis, Lipopolysaccharide Receptors, ANGIOGENESIS, Breast cancer, 0302 clinical medicine, Cell Movement, Risk Factors, CD14 positive macrophages, Chemokine CCL2, Innate immunity, biology, CD68, Biopsy, Needle, DISTINCT SUBSETS, General Medicine, Middle Aged, Immunohistochemistry, Primary tumor, 3. Good health, Phenotype, Treatment Outcome, MONOCYTES, 030220 oncology & carcinogenesis, Female, CCL2, Prognostic markers in breast cancer, Stromal cell, CD14, 3122 Cancers, INHIBITION, Breast Neoplasms, Pathology and Forensic Medicine, 03 medical and health sciences, Immune system, Predictive Value of Tests, Biomarkers, Tumor, medicine, Humans, Molecular Biology, Innate immune system, business.industry, Macrophages, Cell Biology, medicine.disease, 030104 developmental biology, Cancer research, biology.protein, Neoplasm Recurrence, Local, Stromal Cells, business |
| الوصف: | Macrophages are important for the function of the innate immune system, and in solid tumors, they represent a significant proportion of the tumor mass. Tumor-associated macrophages (TAM) have a M2 phenotype and show a multitude of pro-tumoral functions, promoting tumor cell survival, proliferation, and dissemination. CCL2, synthesized by tumor and stromal cells, initiates a chemokine cascade inducing these processes. We studied by immunohistochemistry (IHC) the frequency of TAMs and CCL2 expressing cells in three groups of primary tumor (PT)-recurrence (R) pairs, where relapse was recorded within 2years (group 1), between 5 and 10years (group 2), and after 10years (group 3). In our study all established breast cancers were heavily infiltrated by CD68 positive cells. Both in PTs and in R lesions the infiltration was more abundant in the peritumoral than in the intratumoral stroma. The mean frequency of M2 marker and CD14 positive cells in the intratumoral stroma and CCL2 expressing tumor cells was higher in the Rs as compared to the corresponding PTs. In PTs, a high frequency of CD14 positive cells and a high expression of CCL2 by tumor cells was associated with an early recurrence. The findings support the current understanding of immune cell orchestrated development, progression and metastatic spread of breast cancer. Our study showed that a high frequency of CCL2 positive tumor cells and CD14 positive TAMs are significant risk factors for rapid tumor recurrence. Potential targets for intervention are discussed. |
| تدمد: | 1432-2307 0945-6317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e89fe15463478303c93d9ac5051abfdTest https://doi.org/10.1007/s00428-018-2461-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e89fe15463478303c93d9ac5051abfd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322307 09456317 |
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