التفاصيل البيبلوغرافية
| العنوان: |
Pharmacokinetics and therapeutic efficacy of levamisole in Ascaridia galli experimentally infected ducks. |
| المؤلفون: |
Tabari, Mohaddeseh Abouhosseini1 (AUTHOR), Poźniak, Błażej1,2 (AUTHOR), Mostafavi niaki, Seyedeh Talayeh1,3 (AUTHOR), Salehi, Alireza1,4 (AUTHOR), Youssefi, Mohammad Reza1,5 (AUTHOR) youssefi929@hotmail.com |
| المصدر: |
Veterinary Parasitology. Dec2022, Vol. 312, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*TREATMENT effectiveness, *DUCKS, *ORAL drug administration, *LEVAMISOLE, *PHARMACOKINETICS, *BIOAVAILABILITY |
| مستخلص: |
This study investigated the pharmacokinetics and therapeutic efficacy of levamisole (LVS) after intravenous (i.v.) and oral administrations to healthy and Ascaridia galli -infected ducks by developing an infection model. Twenty-four two-week old ducklings were experimentally infected with A. galli. The ducks were monitored for the development of infection and after 8 weeks they were administered with LVS at a single dose of 30 mg/kg by oral or i.v. administration. Sixteen healthy ducks were subjected to the same treatment and served as control. Serial blood samples were taken for LVS determination with HPLC-UV and pharmacokinetic analysis was carried out based on the non-compartmental approach. The LVS therapeutic efficacy was determined 1 week post drug administration by intestinal worm count at necropsy. In vivo data on development of ascariasis in ducks showed that 8 weeks post inoculation the number of eggs per gram of feces reached at least 100 in each bird. After a single dose of LVS, no parasites were recovered upon necropsy. Results of the pharmacokinetic study showed no statistical differences between infected and non-infected birds for both routes of administration. The mean oral bioavailability was slightly below 50% in both experimental groups. In conclusion, the pharmacokinetics of LVS in ducks was not affected by experimentally-induced ascariasis. A single dose of LVS was found to be efficient against experimental ascariasis in ducks induced by in field isolates of A. galli. • Eight weeks post inoculation of Ascaridia galii eggs, infection was fully developed. • The mean oral bioavailability of levamisole in ducks was about 50%. • A single dose of levamisole was found to be efficient against experimental ascariasis. • No difference was found in pharmacokinetics between infected and non-infected birds. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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