التفاصيل البيبلوغرافية
| العنوان: |
Efficient inactivation of African swine fever virus by a highly complexed iodine. |
| المؤلفون: |
Pan, Li1 (AUTHOR), Luo, Rui1,2 (AUTHOR), Wang, Tao1 (AUTHOR), Qi, Mengnan1 (AUTHOR), Wang, Bing1 (AUTHOR), Sun, Maowen1 (AUTHOR), Luo, Yuzi1 (AUTHOR), Ji, Chen3 (AUTHOR), Sun, Yuan1 (AUTHOR) sunyuan@caas.cn, Qiu, Hua-Ji1,2 (AUTHOR) qiuhuaji@caas.cn |
| المصدر: |
Veterinary Microbiology. Dec2021, Vol. 263, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*AFRICAN swine fever virus, *AFRICAN swine fever, *IODINE, *SWINE diseases, *COMMUNICABLE diseases, *ALVEOLAR macrophages |
| مستخلص: |
• Highly complexed iodine exhibited lower cytotoxicity than traditional povidone-iodine. • Highly complexed iodine completely inactivated ASFV within 5 min. • Highly complexed iodine effectively inactivated ASFV via immersion or spray disinfection. African swine fever (ASF) is a highly lethal contagious disease of swine caused by African swine fever virus (ASFV). Cleaning and disinfection remain one of the most effective tools to prevent the ASFV spread in pig holdings. This study evaluated the inactivation effect of a highly complexed iodine (HPCI) disinfectant against ASFV. A commercially available povidone-iodine (PVP-I) was used as reference for comparison. The results showed that 5% HPCI and 5% PVP-I did not exhibit cytotoxicity in primary porcine alveolar macrophages, and 107.0 and 105.0 TCID 50 /mL ASFV were completely inactivated by 5% and 0.25% HPCI, respectively, in 5 min via either immersion or spray disinfection. However, 5% PVP-I required at least 15 min to completely inactivate 107.0 TCID 50 /mL ASFV, whereas 0.25% PVP-I failed to completely inactivate 105.0 TCID 50 /mL ASFV. This study demonstrated that HPCI could rapidly and efficiently inactivate ASFV, representing an effective disinfectant for ASF control. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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