مورد إلكتروني
Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment
| العنوان: | Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment |
|---|---|
| بيانات النشر: | Wiley 2022-11-17T11:16:35Z 2022-11-17T11:16:35Z 2020-09 |
| تفاصيل مُضافة: | Marconato, Laura Weyland, Mathias S. Tresch, Nina Rossi, Federica Leone, Vito Rohrer Bley, Carla |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Recently, a multimodal approach to oral squamous cell carcinoma (SCC) in cats, combining medical treatment and accelerated radiation therapy, showed a substantial outcome improvement in a small pilot study. Herein we retrospectively review 51 cats with unresectable, histologically confirmed oral SCC and a complete initial staging work-up: cats in group A (n = 24) received medical anti-angiogenic treatment consisting of bleomycin, piroxicam and thalidomide, cats in group B (n = 27) received the anti-angiogenic treatment and concurrent accelerated hypofractionated radiation therapy with 48Gy delivered in 10 fractions. Overall median progression-free interval (PFI) was poor with 70 days (95% CI: 48;93). In the irradiated cats (group B), however, PFI was significantly longer with 179 days (95% CI: 58;301) days, vs 30 days (95% CI: 23;38) in medically only treated cats (P < .001). Overall median overall survival (OS) was 89 days (95% CI: 55;124), again significantly longer in the irradiated cats (group B) with 136 (95% CI: 40;233) vs 38 days (95% CI: 23;54) (P < .001). In 8 of the 27 (29.6%) cats in group B, however, severe toxicity (grade 3) occurred. Neither onset nor severity of toxicity could be associated with any of the tested variables, including anatomic site, tumour size, clinical stage and duration of neoadjuvant medical treatment. Given the potential severe acute effects and the impact on quality of life after chemo-radiotherapy, owners must be clearly informed about the risks of treatment. With the overall poor outcome and high occurrence of acute toxicity, we cannot recommend the use of this accelerated radiation protocol combined with anti-angiogenic therapy for oral SCC in cats. |
| مصطلحات الفهرس: | Bleomycin, Cat, Feline, Metronomic, Oral tumour, Radiation therapy, Side effect, Thalidomide, Animal, Antineoplastic combined chemotherapy protocol, Cat disease, Female, Male, Mouth neoplasm, Radiotherapy, Retrospective study, Squamous cell carcinoma of head and neck, Treatment outcome, Radiation dose hypofractionation, 616: Innere Medizin und Krankheiten, 630: Landwirtschaft, Beitrag in wissenschaftlicher Zeitschrift, Text |
| URL: | Veterinary and Comparative Oncology |
| الإتاحة: | Open access content. Open access content Licence according to publishing contract |
| ملاحظة: | Veterinary and Comparative Oncology English |
| أرقام أخرى: | CHZHA oai:digitalcollection.zhaw.ch:11475/26089 https://doi.org/10.1111/vco.12557Test info:doi/10.1111/vco.12557 https://hdl.handle.net/11475/26089Test https://digitalcollection.zhaw.ch/handle/11475/26089Test info:hdl/11475/26089 urn:issn:1476-5810 urn:issn:1476-5829 31756259 1362715115 |
| المصدر المساهم: | ZHAW UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1362715115 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |