Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.
| العنوان: | Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms. |
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| المؤلفون: | Flondell-Sité, Despina, Lindblad, Bengt, Kölbel, Tilo, Gottsäter, Anders |
| المصدر: | Vascular and Endovascular Surgery. 44(4):262-268 |
| مصطلحات موضوعية: | Aged, 80 and over, Aortic Aneurysm, Abdominal/blood, Biomarkers/blood, Blood Coagulation, Case-Control Studies, Disease Progression, Female, Fibrinolysis, Follow-Up Studies, Humans, Male, Matrix Metalloproteinase 2/blood, Matrix Metalloproteinase 9/blood, Middle Aged, Peptide Hydrolases/blood, Plasminogen Activator Inhibitor 1/blood, Prospective Studies, Protein C/metabolism, Protein C Inhibitor/blood, Sweden, Time Factors, Tissue Inhibitor of Metalloproteinase-1/blood, Tissue Plasminogen Activator/blood, Medicin och hälsovetenskap, Klinisk medicin, Kardiologi, Medical and Health Sciences, Clinical Medicine, Cardiac and Cardiovascular Systems |
| الوصف: | We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth. CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified. |
| الوصول الحر: | https://lup.lub.lu.se/record/1598730Test http://www.ncbi.nlm.nih.gov/pubmed/20356864?dopt=AbstractTest http://dx.doi.org/10.1177/1538574410361971Test |
| قاعدة البيانات: | SwePub |
| تدمد: | 19389116 |
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| DOI: | 10.1177/1538574410361971 |