دورية أكاديمية

Effectiveness of the BNT162b2 mRNA Vaccine Compared with Hybrid Immunity in Populations Prioritized and Non-Prioritized for COVID-19 Vaccination in 2021–2022: A Naturalistic Case-Control Study in Sweden

التفاصيل البيبلوغرافية
العنوان: Effectiveness of the BNT162b2 mRNA Vaccine Compared with Hybrid Immunity in Populations Prioritized and Non-Prioritized for COVID-19 Vaccination in 2021–2022: A Naturalistic Case-Control Study in Sweden
المؤلفون: Armin Spreco, Örjan Dahlström, Anna Jöud, Dennis Nordvall, Cecilia Fagerström, Eva Blomqvist, Fredrik Gustafsson, Jorma Hinkula, Thomas Schön, Toomas Timpka
المصدر: Vaccines, Vol 10, Iss 8, p 1273 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
مصطلحات موضوعية: COVID-19, vaccination program, hybrid immunity, case-control study design, effectiveness, epidemiology, Medicine
الوصف: The term hybrid immunity is used to denote the immunological status of vaccinated individuals with a history of natural infection. Reports of new SARS-CoV-2 variants of concern motivate continuous rethought and renewal of COVID-19 vaccination programs. We used a naturalistic case-control study design to compare the effectiveness of the BNT162b2 mRNA vaccine to hybrid immunity 180 days post-vaccination in prioritized and non-prioritized populations vaccinated before 31 July 2021 in three Swedish counties (total population 1,760,000). Subjects with a positive SARS-CoV-2 test recorded within 6 months before vaccination (n = 36,247; 6%) were matched to vaccinated-only controls. In the prioritized population exposed to the SARS-CoV-2 Alpha and Delta variants post-vaccination, the odds ratio (OR) for breakthrough infection was 2.2 (95% CI, 1.6–2.8; p < 0.001) in the vaccinated-only group compared with the hybrid immunity group, while in the later vaccinated non-prioritized population, the OR decreased from 4.3 (95% CI, 2.2–8.6; p < 0.001) during circulation of the Delta variant to 1.9 (95% CI, 1.7–2.1; p < 0.001) with the introduction of the Omicron variant (B.1.617.2). We conclude that hybrid immunity provides gains in protection, but that the benefits are smaller for risk groups and with circulation of the Omicron variant and its sublineages.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-393X
46199535
العلاقة: https://www.mdpi.com/2076-393X/10/8/1273Test; https://doaj.org/toc/2076-393XTest
DOI: 10.3390/vaccines10081273
الوصول الحر: https://doaj.org/article/4d19b2bc909b41dcb46199535a6d8336Test
رقم الانضمام: edsdoj.4d19b2bc909b41dcb46199535a6d8336
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2076393X
46199535
DOI:10.3390/vaccines10081273