Efficacy of Two Chlamydia abortus Subcellular Vaccines in a Pregnant Ewe Challenge Model for Ovine Enzootic Abortion
| العنوان: | Efficacy of Two Chlamydia abortus Subcellular Vaccines in a Pregnant Ewe Challenge Model for Ovine Enzootic Abortion |
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| المؤلفون: | Cecilia Corbett, Kim Wilson, Morag Livingstone, Javier Palarea-Albaladejo, Mara Rocchi, Michelle Sait, Kevin Aitchison, Nick Wheelhouse, Sean Wattegedera, Gary Entrican, Francesca Chianini, David Longbottom |
| المصدر: | Vaccines, Vol 9, Iss 898, p 898 (2021) Vaccines, 2021, vol. 9, núm. 8, p. 898 Articles publicats (D-IMA) DUGiDocs – Universitat de Girona instname Vaccines Volume 9 Issue 8 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Biomedical Science Research Group, Immunology, Chlamydia abortus, cytokine analysis, Sheep -- Vaccination, Abortion, serological analysis, Applied microbiology, Antigen, Drug Discovery, medicine, Microbiology Research Group, Pharmacology (medical), Ovelles -- Vacunació, Pharmacology, Attenuated vaccine, Chlamydia, enzootic abortion of ewes, business.industry, Transmission (medicine), Outbreak, vaccine efficacy, medicine.disease, Vaccine efficacy, Immunology and infection, Virology, quantitative real-time polymerase chain reaction (PCR), Infectious Diseases, vaccine development, Health, Reproductive health, Medicine, business |
| الوصف: | Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of commercial inactivated or live whole organism-based vaccines, although both have limitations particularly in terms of efficacy, safety and disease-associated outbreaks. Here we report a comparison of two experimental vaccines (chlamydial outer membrane complex (COMC) and octyl glucoside (OG)-COMC) based on detergent extracted outer membrane preparations of C. abortus and delivered as prime-boost immunisations, with the commercial live vaccine Cevac® Chlamydia in a pregnant sheep challenge model. No abortions occurred in either experimental vaccine group, while a single abortion occurred in the commercial vaccine group. Bacterial shedding, as a measure of potential risk of transmission of infection to naïve animals, was lowest in the COMC vaccinated group, with reductions of 87.5%, 86.4% and 74% observed for the COMC, OG-COMC and live commercial vaccine groups, respectively, compared to the unvaccinated challenge control group. The results show that the COMC vaccine performed the best and is a safer efficacious alternative to the commercial vaccines. However, to improve commercial viability, future studies should optimise the antigen dose and number of inoculations required. |
| وصف الملف: | application/pdf; PDF |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2bd9b22b71f2ea7b6913c577ff4dfdTest https://www.mdpi.com/2076-393X/9/8/898Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1f2bd9b22b71f2ea7b6913c577ff4dfd |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |