التفاصيل البيبلوغرافية
| العنوان: |
A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection. |
| المؤلفون: |
Melgaço, Juliana Gil1,2 jgmelgaco@gmail.com, Morgado, Lucas Nóbrega1 morgadobiomed@yahoo.com.br, Santiago, Marta Almeida3 msantiago@bio.fiocruz.br, Oliveira, Jaqueline Mendes de2 jackie@ioc.fiocruz.br, Lewis-Ximenez, Lia Laura4 lialewis.fiocruz@gmail.com, Hasselmann, Bárbara4 barbarahasselmann@gmail.com, Cruz, Oswaldo Gonçalves5 ogcruz@gmail.com, Pinto, Marcelo Alves2 marcelop@ioc.fiocruz.br, Vitral, Claudia Lamarca1 clvitral@id.uff.br |
| المصدر: |
Vaccine. Jul2015, Vol. 33 Issue 32, p3813-3820. 8p. |
| مصطلحات موضوعية: |
*HEPATITIS A vaccines, *ANTIBODY formation, *DRUG dosage, *HEALTH programs, *HEPATITIS A, *IMMUNIZATION, *PREVENTION |
| مستخلص: |
Based on current studies on the effects of single dose vaccines on antibody production, Latin American countries have adopted a single dose vaccine program. However, no data are available on the activation of cellular response to a single dose of hepatitis A. Our study investigated the functional reactivity of the memory cell phenotype after hepatitis A virus (HAV) stimulation through administration of the first or second dose of HAV vaccine and compared the response to that of a baseline group to an initial natural infection. Proliferation assays showed that the first vaccine dose induced HAV-specific cellular response; this response was similar to that induced by a second dose or an initial natural infection. Thus, from the first dose to the second dose, increase in the frequencies of classical memory B cells, TCD8 cells, and central memory TCD4 and TCD8 cells were observed. Regarding cytokine production, increased IL-6, IL-10, TNF, and IFNγ levels were observed after vaccination. Our findings suggest that a single dose of HAV vaccine promotes HAV-specific memory cell response similar to that induced by a natural infection. The HAV-specific T cell immunity induced by primary vaccination persisted independently of the protective plasma antibody level. In addition, our results suggest that a single dose immunization system could serve as an alternative strategy for the prevention of hepatitis A in developing countries. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
