التفاصيل البيبلوغرافية
| العنوان: |
Neutralizing antibody and T-cell responses against SARS-CoV-2 variants by heterologous CoronaVac/ChAdOx-1 vaccination in elderly subjects with chronic obstructive pulmonary disease. |
| المؤلفون: |
Chaiwong, Warawut1 (AUTHOR), Takheaw, Nuchjira1,2,3 (AUTHOR), Pata, Supansa1,2,3 (AUTHOR), Laopajon, Witida2,3 (AUTHOR), Duangjit, Pilaiporn1 (AUTHOR), Inchai, Juthamas1 (AUTHOR), Pothirat, Chaicharn1 (AUTHOR), Bumroongkit, Chaiwat1 (AUTHOR), Deesomchok, Athavudh1 (AUTHOR), Theerakittikul, Theerakorn1 (AUTHOR), Limsukon, Atikun1 (AUTHOR), Tajarernmuang, Pattraporn1 (AUTHOR), Niyatiwatchanchai, Nutchanok1 (AUTHOR), Trongtrakul, Konlawij1 (AUTHOR), Chuensirikulchai, Kantinan2,3 (AUTHOR), Cheyasawan, Passaworn3 (AUTHOR), Liwsrisakun, Chalerm1 (AUTHOR) chalerm.liw@cmu.ac.th, Kasinrerk, Watchara1,2,3 (AUTHOR) Watchara.k@cmu.ac.th |
| المصدر: |
Vaccine. Sep2023, Vol. 41 Issue 40, p5901-5909. 9p. |
| مصطلحات موضوعية: |
*CHRONIC obstructive pulmonary disease, *SARS-CoV-2, *SARS-CoV-2 Delta variant, *ANTIBODY formation, *IMMUNOSENESCENCE, *IMMUNOGLOBULINS, *VACCINATION |
| مصطلحات جغرافية: |
CHAD |
| مستخلص: |
Data on humoral and cellular immune responses against SARS-CoV-2 after receiving heterologous CoronaVac/ChAdOx-1 (CoVac/ChAd) vaccination in subjects with chronic obstructive pulmonary disease (COPD) are still limited. Therefore, we determined the neutralizing antibody (NAb) and T-cell responses against SARS-CoV-2 wild type (WT) and variants of concern (VOCs) in COPD patients. The levels of NAb as well as specific CD4 and CD8 T-cell responses against SARS-CoV-2 WT and VOCs were determined in COPD patients before and after vaccination. Four weeks after vaccinations, the median levels of % inhibition of NAb against SARS-CoV-2 WT, Alpha, Beta, and Delta variants were significantly higher compared to pre-vaccination. The induction of NAb against Omicron was very low compared to other variants. At four weeks after vaccination, in comparison to pre-vaccination, the increasing trend of TNF-α-, IFN-γ-, IL-4-, IL-17-, IL-10-, and FasL-producing CD4 T-cells upon stimulation with WT spike peptides were demonstrated. No difference in T-cell responses to spike peptides of Alpha, Beta, and Delta variants and their WT homologs was observed. Heterologous CoVac/ChAd vaccine induced the production of NAb against SARS-CoV-2 WT, Alpha, Beta, and Delta variants, but low for Omicron in COPD patients. Induction of CD4 T-cell subset responses was slightly observed by this vaccine regimen. Clinical Trials Registry: This study was approved by the Clinical Trials Registry (Study ID: TCTR20210822002). [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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