Fetal Growth Restriction and Schizophrenia: A Swedish Twin Study
| العنوان: | Fetal Growth Restriction and Schizophrenia: A Swedish Twin Study |
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| المؤلفون: | Nilsson, E., Stalberg, G., paul lichtenstein, Cnattingius, S., Olausson, Po, Hultman, Cm |
| المصدر: | Karolinska Institutet |
| بيانات النشر: | Cambridge University Press (CUP), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Sweden, Fetal Growth Retardation, Infant, Newborn, Obstetrics and Gynecology, Fetal Development, Pregnancy, Pediatrics, Perinatology and Child Health, Diseases in Twins, Schizophrenia, Birth Weight, Humans, Female, Prospective Studies, Genetics (clinical) |
| الوصف: | Obstetric complications increase the risk of schizophrenia. However, it is not known whether there is a causal relation or whether the association is mediated by genetic and/or shared environmental effects. The aim of this study was to investigate the associations between birthweight, other birth characteristics, and schizophrenia. Twin pairs discordant for schizophrenia will also control for unmeasured genetic and shared environmental effects. Prospectively filed obstetric records were used for a cohort analysis of 11,360 same-sexed twins, and within–twin pair analyses were conducted on 90 twin pairs discordant for schizophrenia. The results from the cohort study showed that low birthweight (less than or equal to 1999 grams; odds ratio [OR] 1.67, 95% confidence interval [CI] 0.88–3.14 and 2000–2299 grams; OR 1.79, 95% CI 1.07–3.01) and small head circumference (less than or equal to 31.5 cm; OR 1.61, 95% CI 1.03–2.51) were associated with later development of schizophrenia. The associations remained in the within-pair analyses. The association between low birthweight and schizophrenia is partly a function of reduced fetal growth. Fetal growth restriction seems to be associated with risk of schizophrenia independently of familial factors. |
| تدمد: | 1839-2628 1832-4274 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696e40f26eb0fffc6ea5999d5a37fd2eTest https://doi.org/10.1375/twin.8.4.402Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....696e40f26eb0fffc6ea5999d5a37fd2e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18392628 18324274 |
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