دورية أكاديمية
Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS)
| العنوان: | Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS) |
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| المؤلفون: | Melek BUYUK, Yasemin OZLUK, Dogu VURALLI BAKKALOGLU, Berker OZKAN, Pinar FIRAT, Dilek YILMAZBAYHAN |
| المصدر: | Türk Patoloji Dergisi, Vol 39, Iss 1, Pp 64-74 (2023) |
| بيانات النشر: | Federation of Turkish Pathology Societies, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | lung adenocarcinoma, mucin expression, immunohistochemistry, muc1, immune reactivity score, Pathology, RB1-214 |
| الوصف: | Objective: Lung adenocarcinomas are divided into acinar, lepidic, papillary, micropapillary, and solid predominant subtypes according to the current World Health Organization (WHO) classification. We designed this retrospective study to demonstrate profiles of MUC expression (MUC1, MUC2, MUC5AC, and MUC6) of different histologic patterns within the same tumor among pulmonary adenocarcinomas and investigate correlations of MUC expression with clinicopathologic features. Material and Method: We analyzed the expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) in a series of 99 resected lung adenocarcinomas, which included a total of 193 patterns (71 acinar, 30 lepidic, 25 papillary, 20 micropapillary, 34 solid and 13 mucinous) and calculated a final immune reactivity score (FIRS) per tumor. Results: MUC1 IRS scores were significantly higher in lepidic and solid patterns compared with mucinous patterns (p=0.013). MUC2 expression was seen only in three cases (1 acinar, 2 mucinous). MUC5AC and MUC2 expression was more common in mucinous patterns (p8.5 (p=0.018) were significant predictors for lymph node metastasis. Conclusion: An alternative scoring for MUC1 can be used as a predictor for lymph node metastasis regardless of the histologic subtype. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1018-5615 1309-5730 |
| العلاقة: | http://www.turkjpath.org/pdf.php3?id=2029Test; https://doaj.org/toc/1018-5615Test; https://doaj.org/toc/1309-5730Test |
| DOI: | 10.5146/tjpath.2022.01593 |
| الوصول الحر: | https://doaj.org/article/97ba1ccfe80c493caa779839aa26b24dTest |
| رقم الانضمام: | edsdoj.97ba1ccfe80c493caa779839aa26b24d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10185615 13095730 |
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| DOI: | 10.5146/tjpath.2022.01593 |