Acriflavine-Induced Surface Changes in Three Tumor Cell Types and Differential Sensitivity to Lectins
| العنوان: | Acriflavine-Induced Surface Changes in Three Tumor Cell Types and Differential Sensitivity to Lectins |
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| المؤلفون: | Nityagopal Chakraborty, Jayasree Roy Chowdhury, Satya Ranjan Bose |
| المصدر: | Tumori Journal. 70:127-130 |
| بيانات النشر: | SAGE Publications, 1984. |
| سنة النشر: | 1984 |
| مصطلحات موضوعية: | Male, Agglutination, Cancer Research, Cell type, Lymphoma, Cell, chemical and pharmacologic phenomena, 030218 nuclear medicine & medical imaging, Cell membrane, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Concanavalin A, medicine, Animals, Acriflavine, Phytohemagglutinins, Carcinoma, Ehrlich Tumor, Sarcoma 180, Cells, Cultured, biology, Aminoacridines, Cell Membrane, General Medicine, medicine.disease, Molecular biology, Agglutination (biology), medicine.anatomical_structure, Oncology, chemistry, 030220 oncology & carcinogenesis, biology.protein |
| الوصف: | Phytohemagglutinin (PHA) and concanavalin A (Con A) were used as probes to detect changes in the cell surface of Dalton's lymphoma, sarcoma-180 and Ehrlich's carcinoma after short in vitro exposure to acriflavine. Dye-treated cells showed enhancement of agglutination both by PHA and Con A, and such enhancement was found to be dependent on the time of exposure and concentration of acriflavine. However, PHA-induced percent agglutination seemed to be much higher than that of Con A among the 3 cell types. There were also marked differences among the 3 cell types in order of their sensitivity to lectin-mediated agglutination. The strength of the response was greater in lymphoma to both PHA and Con A than that of sarcoma-180 and carcinoma cells, which appeared to be most resistant. Acriflavine, which is known as an intercalative agent with DNA, induces cell surface changes by promoting lectin-mediated cellular agglutination. |
| تدمد: | 2038-2529 0300-8916 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f37eee5e809eb977286fd3c74346e08Test https://doi.org/10.1177/030089168407000203Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7f37eee5e809eb977286fd3c74346e08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20382529 03008916 |
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