دورية أكاديمية
Neoadjuvant crizotinib in advanced inflammatory myofibroblastic tumour with ALK gene rearrangement
| العنوان: | Neoadjuvant crizotinib in advanced inflammatory myofibroblastic tumour with ALK gene rearrangement |
|---|---|
| المؤلفون: | Rafee, Shereen, Elamin, Yasir, Joyce, Eimear, Toner, Mary, Flavin, Richard, McDermott, Ronan, Sheehy, Niall, Hennessy, Bryan, O'Byrne, Ken, Gleeson, Noreen, Osman, Nemer |
| المصدر: | Tumori |
| بيانات النشر: | Wichtig Publishing Srl |
| سنة النشر: | 2015 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Inflammatory myofibroblastic tumours, crizotinib, sarcoma |
| الوصف: | Background Inflammatory myofibroblastic tumours (IMTs) are rare sarcomas that were first described in the lung. They are composed of myofibroblastic mesenchymal spindle cells accompanied by an inflammatory infiltrate of plasma cells. Complete resection is the treatment of choice. There is currently no standard treatment for inoperable or recurrent disease. Expression of ALK protein triggered by ALK gene rearrangement at chromosome 2p23 has been found in 36%-60% of IMTs. Case report We report a rapid early response to crizotinib as neoadjuvant therapy, enabling surgical excision of a large ALK-translocated IMT, which resulted in complete disease clearance. To the best of our knowledge, this is the first case in the literature of a patient with IMT in whom crizotinib was used successfully in the neoadjuvant or curative setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Rafee, Shereen, Elamin, Yasir, Joyce, Eimear, Toner, Mary, Flavin, Richard, McDermott, Ronan, Sheehy, Niall, Hennessy, Bryan, O'Byrne, Ken, Gleeson, Noreen, & Osman, Nemer (2015) Neoadjuvant crizotinib in advanced inflammatory myofibroblastic tumour with ALK gene rearrangement. Tumori, 101(2), e35-e39.; https://eprints.qut.edu.au/95221Test/; Faculty of Health; Institute of Health and Biomedical Innovation |
| الإتاحة: | https://doi.org/10.5301/tj.5000245Test https://eprints.qut.edu.au/95221Test/ |
| حقوق: | Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.3BFEEC72 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |