Collagenases (MMP-1, -8 and -13) and Trypsinogen-2 in Fluid from Benign and Malignant Ovarian Cysts
| العنوان: | Collagenases (MMP-1, -8 and -13) and Trypsinogen-2 in Fluid from Benign and Malignant Ovarian Cysts |
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| المؤلفون: | R. Hanemaaijer, Annukka Paju, Y. T. Konttinen, U.-H. Stenman, Mathias Stenman, Arto Leminen, Taina Tervahartiala, Timo Sorsa |
| المصدر: | Tumor Biology. 24:9-12 |
| بيانات النشر: | Springer Science and Business Media LLC, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Pathology, medicine.medical_specialty, Adolescent, Ovary, Biology, Matrix metalloproteinase, Malignancy, Metastasis, Matrix Metalloproteinase 13, medicine, Humans, Trypsin, Cyst, Collagenases, Aged, Ovarian cyst, Proteolytic enzymes, General Medicine, Middle Aged, medicine.disease, Ovarian Cysts, Matrix Metalloproteinase 8, medicine.anatomical_structure, Trypsinogen, Interstitial collagenase, Female, Matrix Metalloproteinase 1 |
| الوصف: | Proteolytic enzymes, such as matrix metalloproteinases (MMPs) and tumor-associated trypsinogens (TAT), play a pivotal role in tumor invasion and metastasis. Among MMPs, the interstitial collagenases (MMP-1, -8 and -13) can initiate collagenolysis. In this study, we have studied the levels of MMP-1, -8 and -13 in relation to the level of trypsinogen-2 in fluid from benign and malignant ovarian cysts. Elevated MMP-8 levels occur in many ovarian cyst fluids, and high MMP-8 levels are associated with malignancy. The concentrations of trypsinogen-2 correlate with those of MMP-8, but it remains to be shown whether trypsin-2 plays a role as its activator in vivo. The strong expression of MMP-8 over MMP-1 and MMP-13 in malignant ovarian tumors may indicate that MMP-8 participates in the protease cascades associated with the invasiveness of ovarian tumors. |
| تدمد: | 1423-0380 1010-4283 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f14701779319b268b26cee3467f2e98Test https://doi.org/10.1159/000070655Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3f14701779319b268b26cee3467f2e98 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230380 10104283 |
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