Overexpression of zinc finger E-box binding homeobox factor 1 promotes tumor invasiveness and confers unfavorable prognosis in esophageal squamous cell carcinoma
| العنوان: | Overexpression of zinc finger E-box binding homeobox factor 1 promotes tumor invasiveness and confers unfavorable prognosis in esophageal squamous cell carcinoma |
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| المؤلفون: | Juan Zhang, Wei-Jie Dai, Xiao-Zhong Yang, Xiaofei Chen, Qiong Wang |
| المصدر: | Tumor Biology. 35:11977-11984 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Small interfering RNA, Esophageal Neoplasms, Gene Expression, Biology, Metastasis, Cell Movement, Cell Line, Tumor, Gene expression, medicine, Carcinoma, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, neoplasms, Aged, Neoplasm Staging, Aged, 80 and over, Homeodomain Proteins, Gene knockdown, Zinc Finger E-box-Binding Homeobox 1, General Medicine, Transfection, Middle Aged, Prognosis, medicine.disease, digestive system diseases, Tumor progression, Gene Knockdown Techniques, Carcinoma, Squamous Cell, Disease Progression, Cancer research, Immunohistochemistry, Female, Esophageal Squamous Cell Carcinoma, Neoplasm Grading, Follow-Up Studies, Transcription Factors |
| الوصف: | Zinc finger E-box binding homeobox factor 1 (ZEB1), as a crucial mediator of "epithelial-mesenchymal transition," contributes to malignant progression of various epithelial tumors. However, its involvement in human esophageal squamous cell carcinoma (ESCC) remains unclear. In order to investigate the expression pattern of ZEB1 in ESCC tissues and evaluate its associations with tumor progression and patients' prognosis, 100 pairs of formalin-fixed and paraffin-embedded cancerous and adjacent noncancerous tissues from patients with ESCC were used to detect the expression pattern of ZEB1 by immunohistochemistry. Then, the association between ZEB1 expression, clinicopathological parameters, and prognosis of ESCC was examined. We also performed migration and invasion assays of small interfering RNA (siRNA)-targeted ZEB1-transfected cells in vitro. As a result, expression level of ZEB1 was significantly higher in ESCC tissues compared to that in adjacent noncancerous tissues (P |
| تدمد: | 1423-0380 1010-4283 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a646c280ce9b1c154104b23f4589d7Test https://doi.org/10.1007/s13277-014-2494-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c3a646c280ce9b1c154104b23f4589d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230380 10104283 |
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