The impact of L-type amino acid transporter 1 (LAT1) in human hepatocellular carcinoma
| العنوان: | The impact of L-type amino acid transporter 1 (LAT1) in human hepatocellular carcinoma |
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| المؤلفون: | Juan Li, Yao Chen, Juan Qiang, Xin Wang, Jing Fu, Shu-Fen Chen |
| المصدر: | Tumor Biology. 34:2977-2981 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Carcinoma, Hepatocellular, Gene Expression, Kaplan-Meier Estimate, Biology, Large Neutral Amino Acid-Transporter 1, Downregulation and upregulation, Gene expression, medicine, Carcinoma, Humans, RNA, Messenger, Aged, Proportional Hazards Models, Liver Neoplasms, RNA, General Medicine, Middle Aged, medicine.disease, digestive system diseases, Reverse transcription polymerase chain reaction, Hepatocellular carcinoma, Multivariate Analysis, Cancer research, Biomarker (medicine), Immunohistochemistry, Female |
| الوصف: | Upregulation of L-type amino acid transporter 1 (LAT1) has been reported to be associated with a poor prognosis in a variety of malignant tumors. However, the impact of LAT1 in hepatocellular carcinoma (HCC) remains unclear. The objective of this study was to investigate whether the expression of LAT1 in HCC was associated with established clinicopathological features. Quantitative reverse transcription polymerase chain reaction was used to detect LAT1 mRNA expression in 23 pairs of fresh-frozen HCC tissues and corresponding noncancerous tissues. Results showed that LAT1 mRNA expression level in HCC tissues was significantly higher than that in corresponding noncancerous tissues. To investigate the association between LAT1 protein expression and clinicopathological characteristics of HCC, immunohistochemistry was performed in 148 archived paraffin-embedded HCC samples. High LAT1 expression in HCC was associated significantly with tumor size (P = 0.032), histological differentiation (P = 0.003), and tumor stage (P = 0.01). Kaplan-Meier curves demonstrated that patients with a high expression of LAT1 have a significantly increased risk of shortened survival time. Moreover, stepwise Cox regression showed that LAT1 expression may be an independent prognostic factor. Collectively, our study demonstrated that LAT1was overexpressed in HCC and could be served as a potential prognostic marker. |
| تدمد: | 1423-0380 1010-4283 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da72df6599baf8dfd7423c79e7513648Test https://doi.org/10.1007/s13277-013-0861-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da72df6599baf8dfd7423c79e7513648 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230380 10104283 |
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