التفاصيل البيبلوغرافية
| العنوان: |
Hypotension prediction index guided goal-directed therapy to reduce postoperative acute kidney injury during major abdominal surgery: study protocol for a multicenter randomized controlled clinical trial. |
| المؤلفون: |
Ripollés-Melchor, Javier, Carrasco-Sánchez, Laura, Tomé-Roca, José L., Aldecoa, César, Zorrilla-Vaca, Andres, Lorente-Olazábal, Juan V., Colomina, María J., Pérez, Ana, Jiménez-López, Juan I., Navarro-Pérez, Rosalía, Abad-Gurumeta, Alfredo, Monge-García, Manuel I., Ruiz-Escobar, Alicia, Fernánez-Valdes-Bango, Paula, Espinosa, Ángel V., Pradera, María A. Fuentes, Rueda, Azahara Cortes, Adell-Perez, Ana B., Agarrista-Aguirrezabala, Iker, Amelburu-Egoscozabal, Marta |
| المصدر: |
Trials; 4/29/2024, Vol. 25 Issue 1, p1-19, 19p |
| مصطلحات موضوعية: |
SURGICAL complications, ABDOMINAL surgery, KIDNEYS, CLINICAL trials, RANDOMIZED controlled trials, HOSPITAL admission & discharge, ACUTE kidney failure |
| مستخلص: |
Background: Acute kidney injury (AKI) is a significant postoperative complication associated with increased mortality and hospital costs. Hemodynamic strategies, such as goal-directed therapy, might reduce AKI risk. Predicting and proactively managing intraoperative hypotension may be helpful. This trial aims to investigate if a preemptive hemodynamic strategy guided by the hypotension prediction index (HPI) can decrease the incidence of moderate-to-severe AKI within 30 days following major elective abdominal surgery. Methods: This is an open-label, controlled, multicenter, randomized clinical trial that involves daily patient follow-up until hospital discharge. Inclusion criteria are patients aged over 65 and/or categorized as ASA III or IV physical status, undergoing major elective abdominal surgery (general, urological, or gynecological procedures) via laparoscopic or open approach under general or combined anesthesia. Intervention: In the intervention group, hemodynamic management will be based on the HPI and the advanced functional hemodynamic variables provided by the Hemosphere platform and the AcumenIQ® sensor (Edwards Lifesciences). The primary outcome is the incidence of moderate-to-severe AKI within 7 days post-surgery. Secondary outcomes include postoperative complications and 30-day mortality. Discussion: This study explores the potential of HPI-guided hemodynamic management in reducing AKI after major elective abdominal surgery, with implications for postoperative outcomes and patient care. Trial registration: ClinicalTrials.gov NCT05569265. Registered on October 6, 2022. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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