التفاصيل البيبلوغرافية
| العنوان: |
Understanding the tuberculosis granuloma: the matrix revolutions. |
| المؤلفون: |
Elkington, Paul1 (AUTHOR) p.elkington@soton.ac.uk, Polak, Marta E.1 (AUTHOR), Reichmann, Michaela T.1 (AUTHOR), Leslie, Alasdair2,3 (AUTHOR) |
| المصدر: |
Trends in Molecular Medicine. Feb2022, Vol. 28 Issue 2, p143-154. 12p. |
| مصطلحات موضوعية: |
*COVID-19, *COVID-19 pandemic, *MYCOBACTERIUM tuberculosis, *TUBERCULOSIS, *HOST-parasite relationships, *GRANULOMA |
| مستخلص: |
Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore, TB has killed many more humans than any other pathogen, after prolonged coevolution to optimise its pathogenic strategies. Full understanding of fundamental disease processes in humans is necessary to successfully combat this highly successful pathogen. While the importance of immunodeficiency has been long recognised, biologic therapies and unbiased approaches are providing unprecedented insights into the intricacy of the host–pathogen interaction. The nature of a protective response is more complex than previously hypothesised. Here, we integrate recent evidence from human studies and unbiased approaches to consider how Mtb causes human TB and highlight the recurring theme of extracellular matrix (ECM) turnover. Clinical observations and data from immunomodulatory biologic therapies highlight the complexity of the host–pathogen relationship in human tuberculosis (TB), with both insufficient and excessive immune responses leading to disease. Multiple lines of evidence, in humans and animal models, indicate that local factors within each TB lesion govern the outcome; progression and regression can occur simultaneously. Unbiased analyses of co-expressed gene networks demonstrate the role of excessive inflammation in driving TB pathology. Degradation of the extracellular matrix, in particular by the collagenase matrix metalloproteinase-1, has emerged as a key pathological event in TB from diverse approaches. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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