التفاصيل البيبلوغرافية
| العنوان: |
Epitranscriptomic Code and Its Alterations in Human Disease. |
| المؤلفون: |
Kadumuri, Rajashekar Varma1, Janga, Sarath Chandra1,2,3 scjanga@iupui.edu |
| المصدر: |
Trends in Molecular Medicine. Oct2018, Vol. 24 Issue 10, p886-903. 18p. |
| مصطلحات موضوعية: |
*RNA modification & restriction, *GENE regulatory networks, *RNA interference, *RNA metabolism, *IMMUNOGLOBULINS |
| مستخلص: |
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modifications to date. These developments, together with the recent discovery of writers, readers, and erasers of modifications occurring across a wide range of RNAs and tissue types, have led to a surge in integrative approaches for transcriptome-wide mapping of modifications and protein–RNA interaction profiles of epitranscriptome players. RNA modification maps and crosstalk between them have begun to elucidate the role of modifications as signaling switches, entertaining the notion of an epitranscriptomic code as a driver of the post-transcriptional fate of RNA. Emerging single-molecule sequencing technologies and development of antibodies specific to various RNA modifications could enable charting of transcript-specific epitranscriptomic marks across cell types and their alterations in disease. Highlights A literature survey on RNA modifications reveals that RNA modifications are abundant in tRNAs, rRNAs, snoRNAs, and snRNAs but that their diversity is prominent in tRNAs, rRNAs, and mRNAs followed by snRNAs and snoRNAs. Increasing evidence provides a link between RNA modifications and post-transcriptional regulatory processes. Gene knockout and functional studies report the importance of RNA modifications in human health and disease. Emerging long read direct RNA sequencing technologies and development of antibodies specific to RNA modifications could be promising venues for charting the combinatorial epitranscriptomic code across cell types. Locus- and cell-type-specific combinations of epitranscriptome marks could drive the post-transcriptional regulatory fate of an RNA molecule. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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