التفاصيل البيبلوغرافية
| العنوان: |
RNA-based regulation of pluripotency |
| المؤلفون: |
Wright, Jane E.1, Ciosk, Rafal1 rafal.ciosk@fmi.ch |
| المصدر: |
Trends in Genetics. Feb2013, Vol. 29 Issue 2, p99-107. 9p. |
| مصطلحات موضوعية: |
*CELLULAR control mechanisms, *NON-coding RNA, *PLURIPOTENT stem cells, *CELL differentiation, *GENE expression, *GENETIC transcription, *CARRIER proteins, *MESSENGER RNA |
| مستخلص: |
Pluripotent cells have the unique ability to differentiate into diverse cell types. Over the past decade our understanding of the mechanisms underlying pluripotency, and particularly the role of transcriptional regulation, has increased dramatically. However, there is growing evidence for ‘RNA-based’ regulation of pluripotency. We use this term to describe control of gene expression by RNA-binding proteins (RBPs) and regulatory non-coding RNAs (ncRNAs). These molecules bind to specific elements within mRNAs and, by recruiting various effectors, affect many aspects of mRNA regulation. Here, we discuss the role of RBPs and ncRNAs in both the induction and maintenance of pluripotency. We highlight and contrast examples from pluripotent cell lines and in vivo systems while discussing the connection to transcriptional regulators. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
