التفاصيل البيبلوغرافية
| العنوان: |
AMPK: mediating the metabolic effects of salicylate-based drugs? |
| المؤلفون: |
Steinberg, Gregory R.1 gsteinberg@mcmaster.ca, Dandapani, Madhumita2, Hardie, D. Grahame2 d.g.hardie@dundee.ac.uk |
| المصدر: |
Trends in Endocrinology & Metabolism. Oct2013, Vol. 24 Issue 10, p481-487. 7p. |
| مصطلحات موضوعية: |
*PHYSIOLOGICAL effects of aspirin, *SALICYLATES, *PROTEIN kinases, *ANTI-inflammatory agents, *TREATMENT of diabetes, *CANCER treatment |
| مستخلص: |
Highlights: [•] Salicylates, which include aspirin, are among the oldest drugs known to man. [•] Their known targets, COX1/2, cannot explain all anti-inflammatory actions. [•] Salicylate also activates AMPK by direct binding involving the β1 subunit. [•] By modulating metabolism, this may account for some anti-inflammatory effects. [•] It might also explain beneficial effects of salicylates in diabetes and cancer. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
