دورية أكاديمية
Thiol dioxygenases: from structures to functions.
| العنوان: | Thiol dioxygenases: from structures to functions. |
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| المؤلفون: | Perri, Monica, Licausi, Francesco |
| المصدر: | Trends Biochem Sci ; ISSN:0968-0004 ; Volume:49 ; Issue:6 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | N-degron pathway, cupin, cysteine oxidation, oxygen sensing, sulfinic acid, sulfur metabolism |
| الوصف: | Thiol oxidation to dioxygenated sulfinic acid is catalyzed by an enzyme family characterized by a cupin fold. These proteins act on free thiol-containing molecules to generate central metabolism precursors and signaling compounds in bacteria, fungi, and animal cells. In plants and animals, they also oxidize exposed N-cysteinyl residues, directing proteins to proteolysis. Enzyme kinetics, X-ray crystallography, and spectroscopy studies prompted the formulation and testing of hypotheses about the mechanism of action and the different substrate specificity of these enzymes. Concomitantly, the physiological role of thiol dioxygenation in prokaryotes and eukaryotes has been studied through genetic and physiological approaches. Further structural characterization is necessary to enable precise and safe manipulation of thiol dioxygenases (TDOs) for therapeutic, industrial, and agricultural applications. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.tibs.2024.03.007Test; https://pubmed.ncbi.nlm.nih.gov/38622038Test |
| DOI: | 10.1016/j.tibs.2024.03.007 |
| الإتاحة: | https://doi.org/10.1016/j.tibs.2024.03.007Test https://pubmed.ncbi.nlm.nih.gov/38622038Test |
| حقوق: | Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. |
| رقم الانضمام: | edsbas.DF178787 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.tibs.2024.03.007 |
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