التفاصيل البيبلوغرافية
| العنوان: |
A Rare Case of Disseminated Tuberculosis and Hematological Malignancy in a Heart Transplant Recipient. |
| المؤلفون: |
Slomovich, Sharon1 (AUTHOR), Oh, Kyung Taek1 (AUTHOR), Diakos, Nikolaos A.1 (AUTHOR), Restaino, Susan W.1 (AUTHOR), Clerkin, Kevin J.1 (AUTHOR), Latif, Farhana1 (AUTHOR), Miyauchi, Jeremy T.2 (AUTHOR), Lee, Anna3 (AUTHOR), Sayer, Gabriel T.1 (AUTHOR), Uriel, Nir1 (AUTHOR) nu2126@cumc.columbia.edu |
| المصدر: |
Transplantation Proceedings. Oct2021, Vol. 53 Issue 8, p2626-2629. 4p. |
| مصطلحات موضوعية: |
*HEART transplant recipients, *HEMATOLOGIC malignancies, *PLASMA cell leukemia, *DIAGNOSIS, *TUBERCULOSIS, *MULTINUCLEATED giant cells, *PLASMA cell diseases |
| مستخلص: |
A 77-year-old man who underwent a heart transplant 7 years ago presented with multiple bloody bowel movements. Endoscopic and histologic evaluation revealed chronic active ileitis, granulomatous inflammation, multinucleated giant cells, and a rare, equivocal acid-fast bacterium in the terminal ileum. Positive sputum cultures for Mycobacterium tuberculosis and acid-fast bacilli established a diagnosis of intestinal tuberculosis, and RIPE (rifabutin, isoniazid, pyrazinamide, ethambutol) therapy was initiated. Elevated IgG levels on quantitative immunoglobulin testing and a bone marrow biopsy specimen of ≥60% plasma cells confirmed the diagnosis of multiple myeloma that later transformed into its aggressive form, plasma cell leukemia. Induction chemotherapy was initiated; however, the patient experienced retroperitoneal bleeding and pancytopenias, limiting the continuation of chemotherapy, and as a result, the patient was transitioned to palliative care. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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