دورية
Optimizing Graft-Vs-Tumor Activity for Solid Tumors Following Allogenic BMT
| العنوان: | Optimizing Graft-Vs-Tumor Activity for Solid Tumors Following Allogenic BMT |
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| المؤلفون: | Watt, Sarah, Ktena, Yiouli P., Dionysiou, Margarita, Haile, Azeb, Suru, Aditya, Maalouf, Alexandre, Sharma, Kaushal, Symons, Heather, Llosa, Nicolas J., Cooke, Kenneth R. |
| المصدر: | Transplantation and Cellular Therapy; February 2024, Vol. 30 Issue: 2, Number 2 Supplement 1 pS250-S251, 2p |
| مستخلص: | Pediatric solid tumors are the leading cause of disease-related death in children in the US, and outcomes for patients with metastatic disease is unacceptably poor. Heretofore, neither allogeneic bone marrow transplant (BMT) using matched-related donors nor immune checkpoint inhibition alone has been successful in improving outcomes for patients with high-risk solid tumors. Adding immunotherapy post-transplant represents a novel strategy to enhance the effectiveness of these two strategies beyond either one alone. An ongoing clinical trial combining these approaches (Haplo-BMT and post-transplant nivolumab) is actively accruing pediatric patients with high-risk solid tumors. Preliminary data demonstrate that this combined approach is safe and may improve overall survival. Multi-parameter flow cytometry (whole blood) and immunohistochemistry (tumor samples) have provided strategies to follow immune reconstitution and intra-tumoral immune cell infiltration respectively (Figure 1). |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 26666375 26666367 |
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| DOI: | 10.1016/j.jtct.2023.12.331 |